Elezbawy Baher, Kaló Zoltán, Fasseeh Ahmad, Inotai András, Nemeth Bertalan, Ágh Tamás
Department of Pharmaceutical Sciences, Doctoral School of Semmelweis University, Budapest, Hungary.
Department of Evidence Synthesis, Syreon Middle East, Alexandria, Egypt.
Expert Rev Pharmacoecon Outcomes Res. 2025 Feb;25(2):257-264. doi: 10.1080/14737167.2024.2416249. Epub 2024 Oct 16.
Atopic dermatitis (AD) imposes a hidden burden through its negative effects on quality of life and productivity. We aim to estimate this hidden burden in adults and adolescents in Central and Eastern European (CEE) countries.
We created a burden of disease model to quantify AD's hidden burden. Humanistic burden was calculated by estimating the monetary value of quality-adjusted life years (QALYs) lost, using prevalence data from the Global Burden of Disease study and gross domestic product (GDP) per capita for each country. Indirect economic burden was estimated based on productivity loss from absenteeism and presenteeism, adjusted for labor force participation and unemployment rates. Total hidden burden was determined by combining productivity losses and QALYs lost.
QALY loss due to AD ranged from 1,832 to 58,596 annually in CEE countries, equating to 38 million to approximately 1 billion Euros per country. Productivity losses ranged from 3.6 to 148.9 million Euros annually. The total hidden burden of AD represents 0.11% to 0.43% of the GDP.
Our estimates reflect significant differences in population size, prevalence, and economic strength among CEE countries. Adjusting findings to country-specific GDP provided insights into AD's true hidden burden, offering valuable information for decision-making.
特应性皮炎（AD）通过对生活质量和生产力产生负面影响而带来隐性负担。我们旨在评估中欧和东欧（CEE）国家成年人及青少年中的这一隐性负担。
我们创建了一个疾病负担模型来量化AD的隐性负担。通过使用全球疾病负担研究中的患病率数据和各国人均国内生产总值（GDP）来估计损失的质量调整生命年（QALY）的货币价值，从而计算人文负担。间接经济负担是根据旷工和出勤主义导致的生产力损失来估计的，并根据劳动力参与率和失业率进行了调整。总隐性负担是通过将生产力损失和QALY损失相加来确定的。
在中东欧国家，AD导致的QALY损失每年在1832至58596之间，相当于每个国家3800万至约10亿欧元。生产力损失每年在360万至1.489亿欧元之间。AD的总隐性负担占GDP的0.11%至0.43%。
我们的估计反映了中东欧国家在人口规模、患病率和经济实力方面的显著差异。根据各国特定的GDP调整结果，深入了解了AD真正的隐性负担，为决策提供了有价值的信息。
