吲哚-3-甲醇及其主要衍生物 3,3'-二吲哚甲烷：在肝脏疾病中的调控作用和治疗潜力。

Indole-3-carbinol and its main derivative 3,3'-diindolylmethane: Regulatory roles and therapeutic potential in liver diseases.

机构信息

Hepatopancreatobiliary Center, Ministry of Education Key Laboratory of Digital Intelligence Hepatology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine of Tsinghua University, Beijing 102218, China; Research and Development Department, Guangdong Longsee Biomedical Corporation, Guangzhou 510700, China.

出版信息

Biomed Pharmacother. 2024 Nov;180:117525. doi: 10.1016/j.biopha.2024.117525. Epub 2024 Oct 10.

DOI:10.1016/j.biopha.2024.117525

PMID:39388997

Abstract

Indole-3-carbinol (I3C), a compound found in cruciferous vegetables, has shown significant efficacy in treating both cancerous and non-cancerous diseases. Its primary derivative, 3,3'-diindolylmethane (DIM), formed during digestion, also exhibits similar therapeutic benefits. In liver disorders, I3C and DIM exhibit dual roles by inhibiting and promoting hepatocellular carcinoma (HCC) and providing relief for nonmalignant liver diseases, such as acute liver injury (ALI), hepatic fibrosis, nonalcoholic fatty liver disease (NAFLD), and alcohol-related liver disease (ALD). Mechanistically, I3C and DIM modulate various pathophysiological processes, including cell proliferation, apoptosis, oxidative stress, and lipogenesis. This review aims to enhance researchers' understanding of the regulatory roles of I3C and DIM in these liver diseases and explore the potential of plant-derived substances in liver disease treatment.

摘要

吲哚-3-甲醇（I3C）是十字花科蔬菜中发现的一种化合物，已被证明在治疗癌症和非癌症疾病方面具有显著疗效。其主要衍生物 3,3'-二吲哚甲烷（DIM）在消化过程中形成，也表现出类似的治疗益处。在肝脏疾病中，I3C 和 DIM 通过抑制和促进肝癌（HCC）以及缓解非恶性肝脏疾病（如急性肝损伤（ALI）、肝纤维化、非酒精性脂肪性肝病（NAFLD）和酒精相关肝病（ALD））发挥双重作用。在机制上，I3C 和 DIM 调节多种病理生理过程，包括细胞增殖、细胞凋亡、氧化应激和脂肪生成。本综述旨在增强研究人员对 I3C 和 DIM 在这些肝脏疾病中的调节作用的理解，并探索植物源性物质在肝脏疾病治疗中的潜力。