南澳大利亚州发生的一系列涉及赛拉嗪、苯并咪唑类阿片（硝氮烯）和新型苯二氮䓬的多药中毒事件。
A cluster of multi-drug intoxications involving xylazine, benzimidazole opioids (nitazenes) and novel benzodiazepines in South Australia.
作者信息
Partridge Emma, Stockham Peter, Kenneally Michaela, Luong Andrew, Kostakis Chris, Alfred Sam
机构信息
Forensic Science SA (Toxicology), Adelaide, South Australia, Australia.
College of Science and Engineering, Flinders University, Bedford Park, South Australia, Australia.
出版信息
Emerg Med Australas. 2025 Feb;37(1):e14512. doi: 10.1111/1742-6723.14512. Epub 2024 Oct 10.
OBJECTIVE
To highlight the detection of xylazine and nitrazolam in conjunction with benzimidazole opioids (nitazenes) and other novel benzodiazepines in a cluster of patients after putative heroin use.
METHODS
Deidentified clinical and analytical data were gathered from patients enrolled in the Emerging Drugs Network of Australia system.
RESULTS
In December 2023, three adults presented to the ED with sedation following putative use of heroin. Toxicological analysis of blood samples identified xylazine, protonitazene, metonitazene, bromazolam and nitrazolam. Local health authorities subsequently issued an alert.
CONCLUSION
This is the first signal of xylazine and nitrazolam use in Australia. These results demonstrate toxico-surveillance programmes with analytical confirmation of drugs are invaluable in monitoring illicit drug use.
目的
强调在一群疑似使用海洛因的患者中检测到甲苯噻嗪和硝甲西泮，以及它们与苯并咪唑类阿片药物（硝氮烯）和其他新型苯二氮䓬类药物同时出现的情况。
方法
从澳大利亚新兴药物网络系统登记的患者中收集去识别化的临床和分析数据。
结果
2023年12月，三名成年人在疑似使用海洛因后因镇静作用被送往急诊科。血液样本的毒理学分析确定了甲苯噻嗪、硝甲西泮、美托硝氮烯、溴替唑仑和硝甲西泮。当地卫生当局随后发布了警报。
结论
这是澳大利亚首次出现使用甲苯噻嗪和硝甲西泮的信号。这些结果表明，经药物分析确认的毒物监测计划在监测非法药物使用方面具有重要价值。
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