Department of Medical Administration, Peking University Shenzhen Hospital, Peking University, Shenzhen, China.
School of Public Health, Shenzhen University Medical School, Shenzhen, China.
Sci Rep. 2024 Oct 10;14(1):23682. doi: 10.1038/s41598-024-73891-x.
Urolithiasis, a common and recurrent condition, imposes a significant global health burden. This study investigates the causal relationship between various types of fluid intake and urolithiasis using univariable and multivariable Mendelian randomization (MR) approaches. Genetic data for urolithiasis were obtained from the FinnGen Consortium (n = 400,681), while genetic measures for nine fluid types were sourced from meta-analyses of genome-wide association studies (GWAS). The analysis revealed that genetically predicted coffee intake (OR: 0.571, 95% confidence interval (CI): 0.341-0.958, p = 0.034) and ground coffee intake (OR: 0.219, 95% CI: 0.005-0.923, p = 0.038) were protective factors for upper urinary calculi. Additionally, a standard deviation (SD) increase in tea intake was associated with a 53% reduction in risk (OR: 0.473, 95% CI: 0.320-0.700, p < 0.001). Conversely, milk intake (OR: 1.072, 95% CI: 1.018-1.130) and alcohol intakefrequency (OR: 1.304, 95% CI: 1.083-1.570, p = 0.005) increased the risk of upper urinary calculi. These findings highlight the association of tea with reduced risk of urolithiasis, instead for milk and alcohol intake, in formulating prevention strategies for urolithiasis.
尿石症是一种常见且易复发的疾病，给全球健康带来了重大负担。本研究采用单变量和多变量孟德尔随机化（MR）方法，研究了各种类型的液体摄入与尿石症之间的因果关系。尿石症的遗传数据来自芬兰基因联合会（FinnGen Consortium，n=400681），而 9 种液体类型的遗传测量值则来自全基因组关联研究（GWAS）的荟萃分析。分析结果表明，遗传预测的咖啡摄入量（OR：0.571，95%置信区间（CI）：0.341-0.958，p=0.034）和研磨咖啡摄入量（OR：0.219，95%CI：0.005-0.923，p=0.038）对上尿路结石具有保护作用。此外，茶摄入量每增加一个标准差（SD），风险降低 53%（OR：0.473，95%CI：0.320-0.700，p<0.001）。相反，牛奶摄入量（OR：1.072，95%CI：1.018-1.130）和饮酒频率（OR：1.304，95%CI：1.083-1.570，p=0.005）增加了上尿路结石的风险。这些发现强调了茶与降低尿石症风险之间的关联，而不是牛奶和酒精摄入，这为制定尿石症预防策略提供了依据。
