Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Nutrients. 2023 Aug 28;15(17):3753. doi: 10.3390/nu15173753.
Urolithiasis is a common urological disease with increasing prevalence and high recurrence rates around the world. Numerous studies have indicated reactive oxygen species (ROS) and oxidative stress (OS) were crucial pathogenic factors in stone formation. Dietary polyphenols are a large group of natural antioxidant compounds widely distributed in plant-based foods and beverages. Their diverse health benefits have attracted growing scientific attention in recent decades. Many literatures have reported the effectiveness of dietary polyphenols against stone formation. The antiurolithiatic mechanisms of polyphenols have been explained by their antioxidant potential to scavenge free radicals and ROS, modulate the expression and the activity of endogenous antioxidant and prooxidant enzymes, regulate signaling pathways associated with OS, and maintain cell morphology and function. In this review, we first describe OS and its pathogenic effects in urolithiasis and summarize the classification and sources of dietary polyphenols. Then, we focus on the current evidence defining their antioxidant potential against stone formation and put forward challenges and future perspectives of dietary polyphenols. To conclude, dietary polyphenols offer potential applications in the treatment and prevention of urolithiasis.
尿石症是一种常见的泌尿外科疾病，在世界各地的患病率不断上升，复发率也很高。许多研究表明活性氧（ROS）和氧化应激（OS）是结石形成的关键致病因素。膳食多酚是一大类天然抗氧化化合物，广泛存在于植物性食物和饮料中。它们在健康方面的多种益处，近年来引起了科学界越来越多的关注。许多文献报道了膳食多酚对结石形成的有效性。多酚的抗尿石形成机制可以通过其抗氧化潜力来清除自由基和 ROS、调节内源性抗氧化和促氧化剂酶的表达和活性、调节与 OS 相关的信号通路以及维持细胞形态和功能来解释。在这篇综述中，我们首先描述了 OS 及其在尿石症中的致病作用，并总结了膳食多酚的分类和来源。然后，我们重点介绍了目前定义其抗氧化潜力以对抗结石形成的证据，并提出了膳食多酚的挑战和未来展望。总之，膳食多酚在治疗和预防尿石症方面具有潜在的应用价值。
