Department of General Practice, Zhejiang University School of Medicine Sir Run Run Shaw Hospital, Hangzhou, China.
Sci Rep. 2024 Oct 10;14(1):23714. doi: 10.1038/s41598-024-74792-9.
The purpose of this study was to explore the correlation between Hashimoto's thyroiditis and Metabolic dysfunction-associated fatty liver disease (MAFLD), and at the same time to screen high-risk groups for liver fibrosis in MAFLD, find out the high-risk related indicators. The physical examination population was included as the study subjects and was grouped according to the diagnostic criteria for MAFLD. APRI > 1 or NFS > 0.676 or FIB-4 > 2.67were used to assess people at high risk of liver fibrosis, and logistic regression analysis was used to identify risk factors associated with high risk of liver fibrosis in MAFLD. ROC curves are used to look for indicators of diagnostic value. The proportion of people with Hashimoto's thyroiditis was lower in the MAFLD group. The MAFLD high-risk group for liver fibrosis had higher TSH levels, lower FT3 and FT4 levels, higher TGAB levels, and differences in biochemical markers. Age, BMI, FBG, and AST are risk factors for the high risk of liver fibrosis in MAFLD patients. ROC curve analysis showed that the AUC of age was 0.741 (0.721-0.761), and the optimal stage value was 57.5 years, while the AUC of AST was 0.729 (0.707-0.751), and the optimal cut-off value was 39.5 U/L. Age, BMI, FBG, and AST are risk factors for the high risk of liver fibrosis in MAFLD patients.The age is greater than or equal to 57.5 years, or the AST is greater than or equal to 39.5 U/L, indicating that the MAFLD patients are at high risk of liver fibrosis.
本研究旨在探讨桥本甲状腺炎与代谢相关脂肪性肝病（MAFLD）的相关性，同时筛选 MAFLD 中肝纤维化的高危人群，找出高危相关指标。将体检人群纳入研究对象，根据 MAFLD 的诊断标准进行分组。采用 APRI>1 或 NFS>0.676 或 FIB-4>2.67 评估肝纤维化高危人群，并采用 logistic 回归分析识别 MAFLD 中肝纤维化高危的相关危险因素。使用 ROC 曲线寻找有诊断价值的指标。MAFLD 组桥本甲状腺炎的比例较低。MAFLD 肝纤维化高危人群 TSH 水平较高，FT3、FT4 水平较低，TGAB 水平较高，生化标志物存在差异。年龄、BMI、FBG 和 AST 是 MAFLD 患者肝纤维化高危的危险因素。ROC 曲线分析显示，年龄的 AUC 为 0.741（0.721-0.761），最佳分期值为 57.5 岁，AST 的 AUC 为 0.729（0.707-0.751），最佳截断值为 39.5 U/L。年龄≥57.5 岁或 AST≥39.5 U/L，提示 MAFLD 患者肝纤维化高危。
