Li Qiang, Sun Yu, Fu Mu-Xian, Lin Jin-Hong, Xiao Ji-Chang
Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, 200032 Shanghai, China.
Department of Chemistry, Innovative Drug Research Center, Shanghai University, 200444 Shanghai, China.
J Org Chem. 2024 Nov 1;89(21):16022-16027. doi: 10.1021/acs.joc.4c01847. Epub 2024 Oct 11.
Reductive deoxygenation of alcohols is particularly challenging because of the high bond dissociation energy of the C-OH bond and the poor leaving ability of the hydroxyl group. Herein we describe a PhP═O-catalyzed reductive deoxygenation of benzyl alcohols with PhSiH under an air atmosphere within 30 min of reaction time. The use of catalytic loading of PhP═O enhances the practicality of this protocol.
由于C-OH键的高键解离能以及羟基较差的离去能力，醇的还原脱氧特别具有挑战性。在此，我们描述了在空气气氛下，在30分钟的反应时间内，PhP═O催化苄醇与PhSiH进行还原脱氧反应。使用PhP═O的催化负载量提高了该方法的实用性。
