Department of Pediatric Endocrinology, University of Health Sciences, Umraniye Training and Research Hospital, İstanbul, Türkiye.
Department of Otolaryngology, University of Health Sciences, Umraniye Training and Research Hospital, İstanbul, Türkiye.
J Int Adv Otol. 2024 Sep 26;20(5):426-430. doi: 10.5152/iao.2024.231123.
A relationship exists between autoimmune thyroid disorders and vestibular dysfunction. This study aimed to analyze cervicalevoked myogenic potentials (cVEMP) and video head impulse test (vHIT) results between children with Hashimoto thyroiditis (HT) and healthy controls to determine vestibular end-organ problems. Thirty-six children with HT and 30 healthy subjects were recruited. The main inclusion criteria for the healthy group were the presence of normal thyroid function and no clinical history of vestibular problems. Each participant (both HT and healthy groups) was assessed using audiovestibular tests, cVEMP, and vHIT. There was no significant difference between the groups in terms of cVEMP (p1 and n1) latencies for both ears. There was no significant difference in cVEMP amplitudes (p1-n1 peak-to-peak) between the groups. There were statistically significant differences in the VOR gain of the right and left ears between the groups (P < .001, P < .001). When we considered lower cutoff value as 0.80 for VOR gain, 29 of 36 patients with HT (80.6%) had lower VOR gain scores. Only 1 of 30 healthy participants (3.3%) had a lower VOR gain score. This difference was statistically significant (P < .001). Subclinical vestibulopathy may occur in children with HT. The vHIT seems to be a valuable tool for identifying and screening preclinical vestibular pathologies in this patient group.
自身免疫性甲状腺疾病与前庭功能障碍之间存在一定关系。本研究旨在分析桥本甲状腺炎（HT）患儿与健康对照组之间的颈源性肌源性诱发电位（cVEMP）和视频头脉冲试验（vHIT）结果，以确定前庭终器问题。共招募 36 例 HT 患儿和 30 例健康对照者。健康组的主要纳入标准为甲状腺功能正常且无前庭问题的临床病史。所有参与者（HT 组和健康组）均接受了听觉前庭测试、cVEMP 和 vHIT 评估。双耳 cVEMP（p1 和 n1）潜伏期在两组间无显著差异。两组间 cVEMP 振幅（p1-n1 峰峰值）无显著差异。组间右耳和左耳的 VOR 增益存在统计学差异（P<0.001，P<0.001）。当我们将 VOR 增益的较低截断值设定为 0.80 时，36 例 HT 患者中有 29 例（80.6%）的 VOR 增益评分较低。30 例健康参与者中仅有 1 例（3.3%）的 VOR 增益评分较低。这种差异具有统计学意义（P<0.001）。儿童 HT 患者可能存在亚临床前庭病。vHIT 似乎是识别和筛查该患者群体亚临床前庭病变的一种有价值的工具。
