Mishra Deepak K, Rath Asish, Parihar Mayur, Vinarkar Sushant S, Kundu Anirban
Department of Laboratory Hematology, Tata Medical Center, Kolkata, India.
Department of Molecular Pathology, Tata Medical Center, Kolkata, India.
Int J Lab Hematol. 2025 Feb;47(1):36-40. doi: 10.1111/ijlh.14377. Epub 2024 Oct 11.
There have been considerable advances in diagnosing and treating bleeding disorders. But the scenario remains dismal in resource-constrained settings in low and lower-middle-income countries (LMICs). Seventy-five percent of the patients with inherited bleeding disorders do not get diagnosed in LMICs. In resource-constrained settings, infectious disease and malignancies take the major focus. Bleeding disorders do not get prioritised in LMICs, and this leads to underdiagnoses and suboptimal treatment. There are various challenges like financial status, inadequacy of health care infrastructure, lack of patient registry and lack of awareness across medical staff, general population and government stakeholders. The lack of skilled laboratory personnel and laboratory infrastructure for optimal bleeding disorder diagnosis adds on to the problem. World Federation of Hemophilia (WFH) has been at the forefront in developing strategies to overcome some of these inadequacies; however, more active participation of the stakeholders including patients, medical professionals and policy makers is the need of the hour. This review highlights the different challenges in LMICs in diagnosing bleeding disorders, the gap between high-income countries and LMICs and the possible strategies in closing the gap.
在出血性疾病的诊断和治疗方面已经取得了相当大的进展。但在低收入和中低收入国家(LMICs)资源有限的情况下,情况仍然不容乐观。在LMICs中,75%的遗传性出血性疾病患者未得到诊断。在资源有限的情况下,传染病和恶性肿瘤成为主要关注点。出血性疾病在LMICs中未得到优先重视,这导致诊断不足和治疗不充分。存在各种挑战,如财务状况、医疗保健基础设施不足、缺乏患者登记以及医务人员、普通民众和政府利益相关者缺乏认识。缺乏熟练的实验室人员和用于最佳出血性疾病诊断的实验室基础设施加剧了这一问题。世界血友病联盟(WFH)一直处于制定战略以克服其中一些不足的前沿;然而,当务之急是包括患者、医学专业人员和政策制定者在内的利益相关者更积极地参与。本综述强调了LMICs在诊断出血性疾病方面的不同挑战、高收入国家与LMICs之间的差距以及缩小差距的可能策略。