Song Aoqun, Wang Yunting, Liu Cuifang, Yu Juan, Zhang Zixu, Lan Liting, Lin Haiyan, Zhao Jicheng, Li Guohong
New Cornerstone Science Laboratory, Frontier Science Center for Immunology and Metabolism, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, 430072, China.
National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Cell Insight. 2024 Aug 23;3(6):100195. doi: 10.1016/j.cellin.2024.100195. eCollection 2024 Dec.
During the development of eukaryote, faithful inheritance of chromatin states is central to the maintenance of cell fate. DNA replication poses a significant challenge for chromatin state inheritance because every nucleosome in the genome is disrupted as the replication fork passes. It has been found that many factors including DNA polymerases, histone chaperones, as well as, RNA Pol II and histone modifying enzymes coordinate spatially and temporally to maintain the epigenome during this progress. In this review, we provide a summary of the detailed mechanisms of replication-coupled nucleosome assembly and post-replication chromatin maturation, highlight the inheritance of chromatin states and epigenome during these processes, and discuss the future directions and challenges in this field.
在真核生物的发育过程中，染色质状态的忠实遗传对于细胞命运的维持至关重要。DNA复制对染色质状态的遗传构成了重大挑战，因为当复制叉通过时，基因组中的每个核小体都会被破坏。已经发现，包括DNA聚合酶、组蛋白伴侣以及RNA聚合酶II和组蛋白修饰酶在内的许多因子在空间和时间上协同作用，以在这一过程中维持表观基因组。在本综述中，我们总结了复制偶联核小体组装和复制后染色质成熟的详细机制，强调了这些过程中染色质状态和表观基因组的遗传，并讨论了该领域的未来方向和挑战。
