Division of Genetics and Development, Krembil Brain Institute, University Health Network, Toronto, ON, Canada.
Institute of Medical Science, University of Toronto, Toronto, ON, Canada.
Exp Biol Med (Maywood). 2024 Sep 26;249:10266. doi: 10.3389/ebm.2024.10266. eCollection 2024.
Traumatic spinal cord injury (SCI) is a devastating and complex condition to treat with no curative options. In the past few decades, rapid advancements in our understanding of SCI pathophysiology as well as the mergence of new treatments has created more optimism. Focusing on clinical translation, this paper provides a comprehensive overview of SCI through its epidemiology, pathophysiology, currently employed management strategies, and emerging therapeutic approaches. Additionally, it emphasizes the importance of addressing the heavy quality of life (QoL) challenges faced by SCI patients and their desires, providing a basis to tailor patient-centric forms of care. Furthermore, this paper discusses the frequently encountered barriers in translation from preclinical models to clinical settings. It also seeks to summarize significant completed and ongoing SCI clinical trials focused on neuroprotective and neuroregenerative strategies. While developing a cohesive regenerative treatment strategy remains challenging, even modest improvements in sensory and motor function can offer meaningful benefits and motivation for patients coping with this highly debilitating condition.
创伤性脊髓损伤（SCI）是一种毁灭性的复杂疾病，目前尚无治愈方法。在过去的几十年中，我们对 SCI 病理生理学的理解迅速发展，以及新治疗方法的出现，带来了更多的乐观情绪。本文侧重于临床转化，通过流行病学、病理生理学、当前采用的管理策略以及新兴治疗方法，全面概述了 SCI。此外，本文强调了应对 SCI 患者及其愿望所面临的沉重生活质量（QoL）挑战的重要性，为量身定制以患者为中心的护理形式提供了基础。此外，本文还讨论了从临床前模型向临床转化中经常遇到的障碍。它还旨在总结针对神经保护和神经再生策略的已完成和正在进行的重要 SCI 临床试验。尽管开发连贯的再生治疗策略仍然具有挑战性，但即使是感觉和运动功能的适度改善，也可以为应对这种高度致残疾病的患者提供有意义的益处和动力。
