Lipschutz Rebecca, Powers Abigail, Minton Sean T, Stenson Anais F, Ely Timothy D, Stevens Jennifer S, Jovanovic Tanja, van Rooij Sanne J H
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, USA.
J Mood Anxiety Disord. 2024 Sep;7. doi: 10.1016/j.xjmad.2024.100065. Epub 2024 Mar 14.
Although there is an established link between smaller hippocampal volume and anxiety, the longitudinal relations between hippocampus structure and anxiety in diverse youth are not well understood. The present longitudinal study investigated hippocampal volumes related to anxiety symptoms in a sample of Black 8-14-year-old youth (N = 64), a population historically underrepresented in neuroimaging research. Smaller hippocampal volumes were associated with greater anxiety symptoms independent of age, sex, intracranial volume and trauma exposure. Exploratory longitudinal analyses showed smaller hippocampal volume as a predictor for anxiety symptoms (n = 37) and not a consequence of anxiety symptoms (n = 32), however results were inconclusive as this finding was no longer significant after correcting for baseline anxiety symptoms. Overall, this data increases our understanding of potential neurobiological mechanisms for anxiety in a high-risk sample of Black youth and suggests future directions into studying trajectories of developmental risk.
尽管海马体体积较小与焦虑之间已确立存在联系，但不同青少年群体中海马体结构与焦虑之间的纵向关系仍未得到充分理解。本纵向研究调查了8至14岁黑人青少年样本（N = 64）中与焦虑症状相关的海马体体积，这一群体在神经影像学研究中历来代表性不足。独立于年龄、性别、颅内体积和创伤暴露因素，较小的海马体体积与更严重的焦虑症状相关。探索性纵向分析显示，较小的海马体体积可作为焦虑症状（n = 37）的预测指标，而非焦虑症状的结果（n = 32），然而，在校正基线焦虑症状后，这一发现不再显著，因此结果尚无定论。总体而言，这些数据增进了我们对高危黑人青少年样本中焦虑潜在神经生物学机制的理解，并为研究发育风险轨迹指明了未来方向。
