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环境因素对培养的鸡背根神经节细胞表型特征表达的影响。

Influence of environmental factors on the expression of phenotypic characters by chicken dorsal root ganglion cells in culture.

作者信息

Barakat I, Droz B

出版信息

Dev Neurosci. 1985;7(5-6):351-63. doi: 10.1159/000112302.

DOI:10.1159/000112302
PMID:3939125
Abstract

Primary sensory neurons were grown under four conditions of culture. The influence of nonneuronal cells, horse serum or both was studied on the phenotypic expression of certain neuronal subpopulations. The number of neurons expressing acetylcholinesterase, alpha-bungarotoxin-binding sites or a high uptake capacity for glutamine was enhanced by nonneuronal cells. The horse serum increases the neuronal subpopulation exhibiting a carbonic anhydrase activity. Certain phenotypic changes fit conditions consistent with an epigenetic induction rather than a cell selection.

摘要

原代感觉神经元在四种培养条件下生长。研究了非神经元细胞、马血清或两者对某些神经元亚群表型表达的影响。非神经元细胞可增加表达乙酰胆碱酯酶、α-银环蛇毒素结合位点或对谷氨酰胺具有高摄取能力的神经元数量。马血清增加了表现出碳酸酐酶活性的神经元亚群。某些表型变化符合表观遗传诱导而非细胞选择的条件。

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引用本文的文献

1
Carbonic anhydrase activity in primary sensory neurons. II. Influence of environmental factors on the phenotypic expression of the enzyme in dissociated cultures of chicken dorsal root ganglion cells.初级感觉神经元中的碳酸酐酶活性。II. 环境因素对鸡背根神经节细胞解离培养物中该酶表型表达的影响。
Cell Tissue Res. 1986;245(3):497-505. doi: 10.1007/BF00218549.