Department of Rheumatology and Immunology, Jiujiang University Affiliated Hospital, Jiujiang, Jiangxi, China.
Front Immunol. 2024 Sep 26;15:1425988. doi: 10.3389/fimmu.2024.1425988. eCollection 2024.
Rheumatoid arthritis (RA) is a common autoimmune disease. Tuberous sclerosis complex(TSC) is a rare autosomal dominant disorder. We report a case of RA with TSC. The patient was a 46-year-old woman with polyarthritis and cough symptoms, rheumatoid arthritis associated interstitial lung disease (RA-ILD) was initially considered, and after more than 3 months of anti-rheumatic treatment, the patient still had cough, and further examination revealed that the patient had lymphangioleiomyomatosis in the lungs, hepatic and renal angiomyolipomas, multiple subependymal nodules, Vertebral osteosclerotic nodules, as well as facial angiofibromas and periungual fibroma, RA was finally diagnosed with TSC, and everolimus 10mg qd was added to anti-rheumatic therapy for 1 month, and the patient's cough symptoms were relieved.
类风湿关节炎（RA）是一种常见的自身免疫性疾病。结节性硬化症（TSC）是一种罕见的常染色体显性遗传病。我们报告了一例 RA 合并 TSC 的病例。患者为 46 岁女性，表现为多关节炎和咳嗽症状，最初考虑为类风湿关节炎相关间质性肺病（RA-ILD），经过 3 个多月的抗风湿治疗后，患者仍有咳嗽，进一步检查发现患者肺部有淋巴管平滑肌瘤病，肝、肾血管平滑肌脂肪瘤，多发室管膜下结节，脊柱骨硬化性结节，以及面部血管纤维瘤和甲周纤维瘤，最终诊断为 RA 合并 TSC，加用依维莫司 10mg qd 治疗 1 个月后，患者咳嗽症状缓解。
