Edwards Timothy, Børsheim Elisabet, Weber Judith L, Diaz Eva C
Arkansas Children's Nutrition Center, Little Rock, AR, United States.
Arkansas Children's Research Institute, Little Rock, AR, United States.
Front Physiol. 2024 Sep 26;15:1358942. doi: 10.3389/fphys.2024.1358942. eCollection 2024.
Cardiorespiratory fitness (CRF) is a vital indicator of health. However, accurately measuring peak oxygen consumption ( O) to determine CRF in children can be challenging. The oxygen uptake efficiency slope (OUES) has been proposed as an alternative metric for predicting O in children, but its accuracy and agreement with measured O remain unclear.
A post hoc analysis was conducted in 94 children (ages 7-10 years) who completed an incremental cycle ergometer test to measure O. Body composition (Dual-energy X-ray absorptiometry) was measured, and fat mass index (FMI, kg/m) and fat-free mass index (FFMI, kg/m) were calculated. OUES was determined using all respiratory data (OUES) collected during the cycle ergometer test and using data only up to 60% of heart rate reserve (OUES). Regression equations to predict O (Pred- O) were derived from simple and multiple linear regression analysis. Bland-Altman analysis assessed the level of agreement between Pred- O and measured O.
OUES (β = 0.46, < 0.0001), age (β = 56.0, = 0.0004), White race (β = 173.3, < 0.0003), FFMI (β = 0.98.6, < 0.000), and FMI (β = -0.40.8, < 0.000) were retained in the final model. The difference between measured O and Pred- O was not different from zero ( = 0.999). There was a positive association between the difference of measured O and Pred- O and the average of the two methods (β = 0.79, = 0.0028).
There was no mean bias between measured O and Pred- O. However, magnitude bias was present even after considering other significant predictors of O (FMI, FFMI, race, and age) in the regression equation. Caution is advised when using OUES to predict O in children.
心肺适能（CRF）是健康的一项重要指标。然而，准确测量儿童的峰值耗氧量（ ）以确定其心肺适能可能具有挑战性。摄氧效率斜率（OUES）已被提议作为预测儿童 的替代指标，但其准确性以及与实测 的一致性仍不明确。
对94名7至10岁完成递增式蹬车测功试验以测量 的儿童进行了事后分析。测量了身体成分（双能X线吸收法），并计算了脂肪量指数（FMI，kg/m ）和去脂体重指数（FFMI，kg/m ）。使用蹬车测功试验期间收集的所有呼吸数据（OUES ）以及仅使用心率储备60%之前的数据（OUES ）来确定OUES。通过简单和多元线性回归分析得出预测 （Pred- ）的回归方程。Bland-Altman分析评估了Pred- 与实测 之间的一致性水平。
最终模型中保留了OUES（β = 0.46， < 0.0001）、年龄（β = 56.0， = 0.0004）、白种人（β = 173.3， < 0.0003）、FFMI（β = 0.98.6， < 0.000）和FMI（β = -0.40.8， < 0.000）。实测 与Pred- 之间的差异与零无显著差异（ = 0.999）。实测 与Pred- 的差异与两种方法的平均值之间存在正相关（β = 0.79， = 0.0028）。
实测 与Pred- 之间不存在平均偏差。然而，即使在回归方程中考虑了 的其他重要预测因素（FMI、FFMI、种族和年龄）后，仍存在大小偏差。在使用OUES预测儿童 时建议谨慎。
