Navitski Anastasia, Sehgal Sakshi, Ballur Kalyani, Layman Lawrence C, Higgins Robert V
Department of Obstetrics and Gynecology, Medical College of Georgia at Augusta University, Augusta, GA, United States.
Medical College of Georgia, Augusta, GA, United States.
Gynecol Oncol Rep. 2024 Sep 24;56:101515. doi: 10.1016/j.gore.2024.101515. eCollection 2024 Dec.
Disorders of sexual development (DSDs) represent a spectrum of conditions characterized by atypical gonadal and/or genital development. The incidence is 1 in 5,000 live births. Patients with DSD may be at increased risk for developing gonadal and reproductive tract tumors. This report summarizes the current knowledge on the risks of gonadal tumors in patients with DSD. Specifically, we focus on ovotesticular DSD (OT-DSD), which accounts for 5% of DSD cases and is defined by the presence of both ovarian and testicular tissues in the same individual. We present a rare case of a phenotypically male XY patient with OT-DSD who was diagnosed with aggressive peritoneal cancer at the age of 71.
性发育障碍（DSDs）是一系列以性腺和/或生殖器发育异常为特征的病症。发病率为每5000例活产中有1例。患有DSD的患者发生性腺和生殖道肿瘤的风险可能会增加。本报告总结了目前关于DSD患者性腺肿瘤风险的知识。具体而言，我们重点关注卵睾性DSD（OT-DSD），它占DSD病例的5%，定义为同一个体中同时存在卵巢和睾丸组织。我们报告一例罕见病例，一名表型为男性的XY型OT-DSD患者，71岁时被诊断为侵袭性腹膜癌。
