Tsukuda M, Sawaki S
Auris Nasus Larynx. 1985;12 Suppl 2:S161-5. doi: 10.1016/s0385-8146(85)80052-3.
Clinically, the prognosis of nasopharyngeal carcinoma is very poor. It is considered that this depends on three factors. The first is the difficulty of early detection of this disease, because the symptoms of this cancer are latent. The second factor is the specificity of the histological character. The third is most important. This cancer cases fall into the extreme failure category of the immuno-surveillance mechanism. Immuno-responsiveness is extremely depressed. Immunological status has been examined and the clinical evaluation of immunotherapy with OK-432 (streptococcal preparation) and lymphocyte transfer has been made. Results are as follows: 1) Deficiencies of cellular immunity could be recognized through the various immunological parameters, such as subsets of peripheral blood lymphocytes. 2) Immunotherapy is indispensable in this cancer, for the above-mentioned reasons. Better results could be obtained with nonspecific immunotherapy, using OK-432. On the other hand, new immunotherapy, using immunologically enforced lymphocytes with Interleukin-2 prevented micrometastasis, one of the worst characteristics of this cancer. Nasopharyngeal carcinoma is a systemic disease. Therefore immunotherapy is indispensable for the treatment of this cancer.
临床上，鼻咽癌的预后非常差。人们认为这取决于三个因素。第一个因素是这种疾病早期检测困难，因为这种癌症的症状很隐匿。第二个因素是组织学特征的特异性。第三个因素最为重要。这类癌症病例属于免疫监视机制的极端失效范畴。免疫反应极度低下。已经对免疫状态进行了检测，并对使用OK-432（链球菌制剂）和淋巴细胞转移进行免疫治疗进行了临床评估。结果如下：1）通过各种免疫参数，如外周血淋巴细胞亚群，可以识别细胞免疫缺陷。2）由于上述原因，免疫治疗在这种癌症中不可或缺。使用OK-432进行非特异性免疫治疗可获得更好的效果。另一方面，使用经白细胞介素-2免疫强化的淋巴细胞进行的新免疫治疗可预防微转移，这是这种癌症最糟糕的特征之一。鼻咽癌是一种全身性疾病。因此，免疫治疗对于这种癌症的治疗是不可或缺的。
