Petithory J C, Weinsberg M, Zatla F
Bull Soc Pathol Exot Filiales. 1985;78(5 Pt 2):836-43.
The tropical splenomegaly syndrome, described by Charmot as a chronic splenomegaly without any acute malaria attack, appears to be the prototype of hyperimmune malaria. A very small number of red cells or even no red cells are infected. IgG and/or IgM rates are greatly increased, as are anti-Plasmodium antibodies. The ratio T. helper/T. suppressor is normal or slightly increased. Serological tests show often cross reactions, mainly with African trypanosomiasis and toxoplasmosis, also with leishmaniasis. Undefined genetic factors in the host could explain the syndrome.
热带脾肿大综合征，被沙尔莫描述为一种无任何急性疟疾发作的慢性脾肿大，似乎是超免疫疟疾的原型。仅有极少数红细胞甚至没有红细胞被感染。免疫球蛋白G和/或免疫球蛋白M水平大幅升高，抗疟原虫抗体水平也同样如此。辅助性T细胞/抑制性T细胞的比例正常或略有升高。血清学检测常显示交叉反应，主要与非洲锥虫病和弓形虫病交叉反应，也与利什曼病交叉反应。宿主中未明确的遗传因素可能解释这一综合征。
