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基于生物信息学和荟萃分析的PSMD14在癌症中的临床病理及预后意义

The clinicopathological and prognostic significance of PSMD14 in cancers based on bioinformatics and meta-analysis.

作者信息

Dong Shu-Yi, Ding Shuxin, Meng Zhen, Zou Bo

机构信息

Department of Oral & Maxillofacial Surgery, Liaocheng People's Hospital, Medical College of Liaocheng University, Liaocheng, Shandong, P. R. China.

Key Laboratory of Oral Maxillofacial-Head & Neck medical biology of Shandong Province, Liaocheng People's Hospital, Liaocheng, Shandong, P. R. China.

出版信息

Future Sci OA. 2024 Dec 31;10(1):2409054. doi: 10.1080/20565623.2024.2409054. Epub 2024 Oct 11.

DOI:10.1080/20565623.2024.2409054
PMID:39392083
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11486200/
Abstract

To evaluate the clinic-pathological features and prognostic value regarding PSMD14 in cancers. Literature was gathered from public databases until 22 June 2023 to analyze data on survival rates and clinicopathological characteristics associated with PSMD14. TCGA and GEO data were also utilized for validation. Eight reports on seven types of tumors showed that high PSMD14 expression was linked to poorer overall survival and disease-free survival. PSMD14 expression also correlated with larger tumor size, differentiation and metastasis, as well as the effectiveness of various chemotherapy drugs. PSMD14 could serve as a potential biomarker of poor prognosis in cancers, including lung cancer, head and neck squamous cell carcinoma, ovarian cancer, breast cancer and hepatocellular carcinoma.

摘要

评估PSMD14在癌症中的临床病理特征及预后价值。从公共数据库收集截至2023年6月22日的文献，以分析与PSMD14相关的生存率和临床病理特征数据。还利用TCGA和GEO数据进行验证。八项关于七种肿瘤类型的报告显示，PSMD14高表达与较差的总生存期和无病生存期相关。PSMD14表达还与更大的肿瘤大小、分化和转移以及各种化疗药物的疗效相关。PSMD14可作为包括肺癌、头颈部鳞状细胞癌、卵巢癌、乳腺癌和肝细胞癌在内的癌症预后不良的潜在生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1735/11486200/dc2d32fa9add/IFSO_A_2409054_F0008_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1735/11486200/a2773768a385/IFSO_A_2409054_F0001_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1735/11486200/d11da7e3ae61/IFSO_A_2409054_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1735/11486200/e5300e619ea5/IFSO_A_2409054_F0003A_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1735/11486200/063de1e72e7f/IFSO_A_2409054_F0003B_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1735/11486200/08219b2dfb1a/IFSO_A_2409054_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1735/11486200/617d6a6024df/IFSO_A_2409054_F0005_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1735/11486200/a9e691678b44/IFSO_A_2409054_F0006_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1735/11486200/03b5dd129982/IFSO_A_2409054_F0007_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1735/11486200/dc2d32fa9add/IFSO_A_2409054_F0008_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1735/11486200/a2773768a385/IFSO_A_2409054_F0001_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1735/11486200/d11da7e3ae61/IFSO_A_2409054_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1735/11486200/e5300e619ea5/IFSO_A_2409054_F0003A_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1735/11486200/063de1e72e7f/IFSO_A_2409054_F0003B_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1735/11486200/08219b2dfb1a/IFSO_A_2409054_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1735/11486200/617d6a6024df/IFSO_A_2409054_F0005_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1735/11486200/a9e691678b44/IFSO_A_2409054_F0006_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1735/11486200/03b5dd129982/IFSO_A_2409054_F0007_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1735/11486200/dc2d32fa9add/IFSO_A_2409054_F0008_C.jpg

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Oncogene. 2024 Jan;43(4):248-264. doi: 10.1038/s41388-023-02905-1. Epub 2023 Nov 29.
3
Impact of risk factors on early cancer evolution.
危险因素对早期癌症演变的影响。
Cell. 2023 Apr 13;186(8):1541-1563. doi: 10.1016/j.cell.2023.03.013.
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Six immune-related promising biomarkers may promote hepatocellular carcinoma prognosis: a bioinformatics analysis and experimental validation.六种免疫相关的潜在生物标志物可能改善肝细胞癌预后：一项生物信息学分析及实验验证
Cancer Cell Int. 2023 Mar 23;23(1):52. doi: 10.1186/s12935-023-02888-9.
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Depletion of PSMD14 suppresses bladder cancer proliferation by regulating GPX4.PSMD14 的耗竭通过调节 GPX4 抑制膀胱癌的增殖。
PeerJ. 2023 Jan 6;11:e14654. doi: 10.7717/peerj.14654. eCollection 2023.
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Deubiquitylase PSMD14 inhibits autophagy to promote ovarian cancer progression via stabilization of LRPPRC.去泛素化酶PSMD14通过稳定LRPPRC抑制自噬以促进卵巢癌进展。
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