Department of Molecular and Clinical Medicine Institute of Medicine Sahlgrenska Academy University of Gothenburg Gothenburg Sweden.
Department of Medicine Geriatrics and Emergency Medicine Region Västra Götaland Sahlgrenska University Hospital/Östra Gothenburg Sweden.
J Am Heart Assoc. 2024 Oct 15;13(20):e034891. doi: 10.1161/JAHA.123.034891. Epub 2024 Oct 11.
Overweight and obesity are increasing globally with aging, as are life expectancy and aging-associated disorders, including calcific aortic stenosis (AS). Studies investigating the correlation between high body mass index (BMI) and AS are contradictory and inconclusive. This study examines a potential association between BMI and AS in women.
By linking the Swedish Medical Birth Register and the Swedish National Patient Register, we included women aged 18 to 55 years with a first childbirth from 1981 to 2020. Diagnosis of AS and comorbidities were defined according to the () codes. The women were divided into groups on the basis of BMI. Cox proportional hazards regression models were used to investigate the difference in the risk of being diagnosed with AS, with reference BMI 20 to <22.5 kg/m. Among the 1 722 625 included women, the mean age was 28 years, and mean BMI was 24 kg/m, with 21% being overweight (BMI 25 to <30 kg/m) and 8.5% obese (BMI ≥30 kg/m). During median follow-up of 19.5 years, 2488 women (0.14%) were diagnosed with AS. The age-adjusted risk of being diagnosed with AS increased with higher BMI to 2.82 (95% CI, 2.44-3.25) times higher in women with BMI 30 to <35 kg/m, and to 3.72 (95% CI, 2.95-4.70) times higher in those with BMI ≥35 kg/m. Similar results were found after excluding AS of rheumatic pathogenesis.
An increase in BMI from its upper normal range was consistently and independently associated with the risk of developing AS in women.
超重和肥胖在全球范围内随着人口老龄化而增加，预期寿命和与衰老相关的疾病也在增加，包括钙化性主动脉瓣狭窄（AS）。研究表明，高体重指数（BMI）与 AS 之间存在相关性，但结果存在争议且尚无定论。本研究旨在探讨女性 BMI 与 AS 之间的潜在相关性。
通过链接瑞典医疗出生登记处和瑞典国家患者登记处，我们纳入了 1981 年至 2020 年间首次分娩的 18 至 55 岁女性。AS 的诊断和合并症是根据国际疾病分类第 10 版（ICD-10）编码定义的。根据 BMI 将女性分为不同的组别。使用 Cox 比例风险回归模型来探讨被诊断为 AS 的风险差异，参考 BMI 为 20 至 <22.5kg/m。在纳入的 1722625 名女性中，平均年龄为 28 岁，平均 BMI 为 24kg/m，其中 21%超重（BMI 为 25 至 <30kg/m），8.5%肥胖（BMI ≥30kg/m）。在中位随访 19.5 年期间，有 2488 名女性（0.14%）被诊断为 AS。与 BMI 为 20 至 <22.5kg/m 的女性相比，BMI 为 30 至 <35kg/m 的女性被诊断为 AS 的风险增加了 2.82 倍（95%CI，2.44-3.25），BMI 为≥35kg/m 的女性增加了 3.72 倍（95%CI，2.95-4.70）。在排除风湿性发病机制所致 AS 后，也得到了类似的结果。
从正常上限增加 BMI 与女性患 AS 的风险呈一致性和独立性相关。
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