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杏仁核与情绪研究的入门途径。

Gateway to the study of the amygdala and emotion.

作者信息

Romanski Lizabeth M

机构信息

Department of Neuroscience, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, United States.

出版信息

Cereb Cortex. 2025 Jan 8;35(1):3-4. doi: 10.1093/cercor/bhae408.

Abstract

The study of the amygdala and its role in the processing of emotions has become a common focus in neuroscience. The modern expansion of research in this area is partly due to the discovery of a subcortical pathway for the transmission of emotional information and the experimental paradigm that was developed to study it. Groundbreaking experiments during the 90s utilized anatomical, neurophysiological, and behavioral lesion studies in a rodent animal model to uncover the neural circuitry of a simple emotional memory. These studies demonstrated the essential role of a specific monosynaptic pathway in emotional memory, using traditional tools and behavioral methods. The development of an animal model with a simple and appropriate classical conditioning paradigm made experimental investigations into the neural basis of emotion tenable and available to a generation of neuroscientists. These tools and a focus on the amygdala's neural connections and their essential role in emotional memory were a driving force in the explosion of research regarding the amygdala and emotion.

摘要

杏仁核及其在情绪处理中的作用的研究已成为神经科学的一个常见焦点。该领域研究的现代扩展部分归因于一条用于传递情绪信息的皮层下通路的发现以及为研究它而开发的实验范式。20世纪90年代的开创性实验在啮齿动物模型中利用解剖学、神经生理学和行为损伤研究来揭示一种简单情绪记忆的神经回路。这些研究使用传统工具和行为方法证明了特定单突触通路在情绪记忆中的重要作用。具有简单且合适的经典条件作用范式的动物模型的开发使得对情绪神经基础的实验研究变得可行,并为一代神经科学家所用。这些工具以及对杏仁核神经连接及其在情绪记忆中的重要作用的关注是关于杏仁核与情绪的研究激增的驱动力。

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