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功能性 RNAi 筛选鉴定出 G2/M 和着丝粒组件作为 TNFα/NF-κB 生存信号在头颈部鳞状细胞癌中的调节剂。

Functional RNAi Screening Identifies G2/M and Kinetochore Components as Modulators of TNFα/NF-κB Prosurvival Signaling in Head and Neck Squamous Cell Carcinoma.

机构信息

Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Communication Disorders, National Institutes of Health, Bethesda, Maryland.

School of Life Sciences, University of Sussex, Brighton, United Kingdom.

出版信息

Cancer Res Commun. 2024 Nov 1;4(11):2903-2918. doi: 10.1158/2767-9764.CRC-24-0274.

DOI:10.1158/2767-9764.CRC-24-0274
PMID:39392349
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11541648/
Abstract

Here, RNAi library screening reveals that multiple G2/M and kinetochore components, including TTK/monopolar spindle 1, modulate TNFα-induced NF-κB activation, cell survival, and genotoxicity, underscoring their potential importance as therapeutic targets in HNSCC.

摘要

在这里，RNAi 文库筛选揭示了多个 G2/M 和着丝粒成分，包括 TTK/单极纺锤体 1，调节 TNFα 诱导的 NF-κB 激活、细胞存活和遗传毒性，强调了它们作为 HNSCC 治疗靶点的潜在重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27d0/11541648/5b591ece353f/crc-24-0274_f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27d0/11541648/fda3d32bd4d0/crc-24-0274_f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27d0/11541648/fd12eae3c1a5/crc-24-0274_f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27d0/11541648/94bef9ed5f3a/crc-24-0274_f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27d0/11541648/5c5a2b4692d2/crc-24-0274_f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27d0/11541648/45c4c9c417f9/crc-24-0274_f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27d0/11541648/713d916f4ba0/crc-24-0274_f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27d0/11541648/5b591ece353f/crc-24-0274_f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27d0/11541648/fda3d32bd4d0/crc-24-0274_f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27d0/11541648/fd12eae3c1a5/crc-24-0274_f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27d0/11541648/94bef9ed5f3a/crc-24-0274_f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27d0/11541648/5c5a2b4692d2/crc-24-0274_f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27d0/11541648/45c4c9c417f9/crc-24-0274_f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27d0/11541648/713d916f4ba0/crc-24-0274_f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27d0/11541648/5b591ece353f/crc-24-0274_f7.jpg

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