系统定量评价醒脑静注射液治疗颅脑损伤患者的基因多态性与疗效。
Systematic quantitative evaluation of gene polymorphism and therapeutic effect of xingnaojing injection in patients with brain injury.
机构信息
Department of Critical Care, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, China.
Infectious Disease Department, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, China.
出版信息
Technol Health Care. 2024;32(6):4801-4818. doi: 10.3233/THC-231864.
BACKGROUND
The incidence of brain injury is increasing year by year, and it has become one of the major diseases threatening human life in today's society. From the perspective of the causes of brain injury, it is mainly due to falls from high places, traffic accidents, etc. Severe brain injury patients often lose consciousness. In recent years, the emergence of integrated traditional Chinese and Western medicine has provided a new approach and new ideas for the treatment of craniocerebral trauma.
OBJECTIVE
The article systematically and scientifically expounded the role of Xingnaojing injection in the treatment of brain injury by comparing the GCS (Glasgow Coma Scale) score, changes in intracranial pressure, the incidence of complications after brain injury, the transformation from moderate brain injury to severe brain injury, and recovery of consciousness.
METHODS
For the problem of gene polymorphism in patients with brain injury, this article discussed the role of APOE2 (Apolipoprotein E2), ε3, ε4 in brain injury. All patients had a clear history of trauma and received strict nervous system examination and CT scanning when they were admitted to the hospital. After craniocerebral trauma surgery or conservative therapy, patients should take a Xingnaojing injection of 30 ml and a 0.9% sodium chloride injection of 250 ml after admission. After the operation, respiratory tract nursing should be strengthened, and patients who cannot eat should be given nasal feeding, acupuncture, and physiotherapy to prevent bedridden complications.
RESULTS
The probability of epilepsy after brain injury was 27%.
CONCLUSION
The article would help to evaluate the degree of brain damage and prognosis of patients.
背景
脑损伤的发病率逐年上升，已成为当今社会威胁人类生命的主要疾病之一。从脑损伤的病因来看，主要是由于高处坠落、交通事故等原因造成的。重度脑损伤患者常失去意识。近年来，中西医结合的出现为颅脑创伤的治疗提供了新的途径和思路。
目的
通过比较 GCS（格拉斯哥昏迷量表）评分、颅内压变化、脑损伤后并发症发生率、从中度脑损伤向重度脑损伤的转化以及意识恢复情况，系统科学地阐述醒脑静注射液在脑损伤治疗中的作用。
方法
针对脑损伤患者的基因多态性问题，本文探讨了 APOE2（载脂蛋白 E2）、ε3、ε4 在脑损伤中的作用。所有患者均有明确的创伤史，并在入院时接受严格的神经系统检查和 CT 扫描。颅脑外伤手术后或保守治疗后，患者入院后应给予醒脑静注射液 30ml 和 0.9%氯化钠注射液 250ml。术后应加强呼吸道护理，对不能进食的患者给予鼻饲、针灸、理疗，预防卧床并发症。
结果
脑损伤后癫痫的概率为 27%。
结论
该文章将有助于评估患者脑损伤的程度和预后。
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