Pasqualini C, Kerdelhue B
C R Acad Sci III. 1985;300(17):637-42.
The effect of estradiol on anterior pituitary dopaminergic receptor content was studied in vivo and in vitro, in relation with the serum PRL secretion. A progressive and significant decrease in the number of these receptors was observed, a few hours before the serum release of PRL induced in ovariectomized females by a sequential treatment with different doses of estradiol benzoate. This decrease in the number of dopaminergic membrane receptors can be obtained as well in vitro, when anterior pituitaries, from ovariectomized rats, are incubated with 17 beta-estradiol. These results suggest that the stimulatory effect of estradiol on PRL secretion may be due, at least in part, to the direct "desensitization" to DA of anterior pituitary cells, which is produced by the decrease of dopaminergic receptor level.
在体内和体外研究了雌二醇对垂体前叶多巴胺能受体含量的影响，并将其与血清催乳素（PRL）分泌相关联。在去卵巢雌性大鼠中，通过连续给予不同剂量的苯甲酸雌二醇诱导血清PRL释放前数小时，观察到这些受体数量逐渐且显著减少。当将去卵巢大鼠的垂体前叶与17β-雌二醇一起孵育时，在体外也可获得多巴胺能膜受体数量的这种减少。这些结果表明，雌二醇对PRL分泌的刺激作用可能至少部分归因于垂体前叶细胞对多巴胺（DA）的直接“脱敏”，这是由多巴胺能受体水平降低所产生的。
