Sedlock M L, Ravitch J, Edwards D J
Neuropharmacology. 1985 Aug;24(8):705-8. doi: 10.1016/0028-3908(85)90002-4.
Acute injections of imipramine and iprindole in rats produced significant decreases in the concentration of p-hydroxyphenylglycol (pHPG), a neutral metabolite of octopamine in brain at 6 and 24 hr after the administration of drugs. The 24-hr urinary levels of both free and total pHPG were reduced to 25-29% of control with acute administration of imipramine, while iprindole produced a 30% decrease in free pHPG. With chronic administration of imipramine, concentrations of pHPG in brain returned to normal, while the 24-hr urinary levels were still decreased (to 24%). Octopamine in brain was unaltered after both single and repeated injections of imipramine. Thus, these data suggest that the turnover of octopamine in brain is reduced after acute administration of imipramine and iprindole, while after chronic treatment with imipramine, turnover of octopamine in brain has returned to control levels.
给大鼠急性注射丙咪嗪和茚满二酮后，在给药后6小时和24小时，脑内对羟基苯乙二醇（pHPG）（章鱼胺的一种中性代谢产物）的浓度显著降低。急性注射丙咪嗪后，游离和总pHPG的24小时尿水平降至对照值的25 - 29%，而茚满二酮使游离pHPG降低了30%。长期给予丙咪嗪后，脑内pHPG浓度恢复正常，而24小时尿水平仍降低（至24%）。单次和重复注射丙咪嗪后，脑内章鱼胺均未改变。因此，这些数据表明，急性注射丙咪嗪和茚满二酮后，脑内章鱼胺的更新率降低，而长期用丙咪嗪治疗后，脑内章鱼胺的更新率已恢复至对照水平。
