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The Arousal Threshold: The "Weakest Link" in Obstructive Sleep Apnea Pathogenesis?

作者信息

Joosten Simon A, Edwards Bradley A, Landry Shane A

机构信息

Monash Lung, Sleep, Allergy, and Immunity Monash Health Clayton, Victoria, Australia.

School of Clinical Sciences Monash University Melbourne, Victoria, Australia.

出版信息

Am J Respir Crit Care Med. 2024 Dec 15;210(12):1396-1397. doi: 10.1164/rccm.202408-1523ED.

Abstract
摘要

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Hypnotics on Obstructive Sleep Apnea Severity and Endotypes: A Systematic Review and Meta-Analysis.
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Obstructive Sleep Apnea Is a Distinct Physiological Endotype in Individuals with Comorbid Insomnia and Sleep Apnea.
Ann Am Thorac Soc. 2023 Oct;20(10):1508-1515. doi: 10.1513/AnnalsATS.202304-350OC.
4
Physiological Traits and Adherence to Sleep Apnea Therapy in Individuals with Coronary Artery Disease.
Am J Respir Crit Care Med. 2021 Sep 15;204(6):703-712. doi: 10.1164/rccm.202101-0055OC.
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Physiological Traits and Adherence to Obstructive Sleep Apnea Treatment in Patients with Stroke.
Am J Respir Crit Care Med. 2020 Jun 15;201(12):1568-1572. doi: 10.1164/rccm.201911-2203LE.
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Lung air trapping lowers respiratory arousal threshold and contributes to sleep apnea pathogenesis in COPD patients with overlap syndrome.
Respir Physiol Neurobiol. 2020 Jan;271:103315. doi: 10.1016/j.resp.2019.103315. Epub 2019 Oct 3.
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Phenotyping Pharyngeal Pathophysiology using Polysomnography in Patients with Obstructive Sleep Apnea.
Am J Respir Crit Care Med. 2018 May 1;197(9):1187-1197. doi: 10.1164/rccm.201707-1435OC.
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The importance of arousal in obstructive sleep apnea-updates from the American Thoracic Society 2016.
J Thorac Dis. 2016 Jul;8(Suppl 7):S542-4. doi: 10.21037/jtd.2016.06.81.

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