饮酒作为抗结核药物性肝损伤的危险因素：系统评价和荟萃分析。
Alcohol consumption as a risk factor for anti-tuberculosis drug induced liver injury: A systematic review and meta-analysis.
机构信息
Department of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, 250012, PR China; Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis & Thoracic Tumor Research Institute, Beijing, 101149, PR China.
Department of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, 250012, PR China; Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis & Thoracic Tumor Research Institute, Beijing, 101149, PR China.
出版信息
Microb Pathog. 2024 Nov;196:107003. doi: 10.1016/j.micpath.2024.107003. Epub 2024 Oct 10.
BACKGROUND
Tuberculosis (TB) is a major infectious disease in the world, and liver injury caused by anti-tuberculosis (ATTB) drugs is an important reason for reduced patient compliance with ATTB treatment. At present, there is controversy over the role of alcohol consumption in ATTB drugs induced liver injury (ATDILI).
METHODS
All data on alcohol consumption and ATDILI were collected from PubMed, Web of Science, Scopus and Embase databases from inception to April 2023. Odds ratio (OR) and 95 % confidence interval (95 % CI) were used for statistical analysis, and Begg test and Egger test were used to evaluate publication bias.
RESULTS
A total of 1152 literatures were reviewed, and 53 literatures were included for systematic review and meta-analysis. Studies have found that alcohol consumption increases the risk of ATDILI (OR: 1.55; 95 % CI: 1.19-2.04). And an increased risk of ATDILI was found in both the alcoholic and non-alcoholic subgroups. The Begg test and Egger test showed no publication bias.
CONCLUSION
Alcohol consumption is a risk factor for ATDILI in TB patients on treatment. While on ATTB treatment, patients need to reduce alcohol consumption. More research is needed to assess the link between alcohol consumption and ATDILI.
背景
结核病（TB）是全球主要的传染病之一，抗结核（ATTB）药物引起的肝损伤是导致患者降低抗结核治疗依从性的重要原因。目前，关于饮酒在抗结核药物引起的肝损伤（ATDILI）中的作用存在争议。
方法
从 PubMed、Web of Science、Scopus 和 Embase 数据库成立至 2023 年 4 月，收集所有关于饮酒和 ATDILI 的数据。采用比值比（OR）和 95%置信区间（95%CI）进行统计学分析，并采用 Begg 检验和 Egger 检验评估发表偏倚。
结果
共回顾了 1152 篇文献，其中 53 篇文献进行了系统评价和荟萃分析。研究发现，饮酒会增加 ATDILI 的风险（OR：1.55；95%CI：1.19-2.04）。在饮酒和非饮酒亚组中均发现 ATDILI 的风险增加。Begg 检验和 Egger 检验显示无发表偏倚。
结论
饮酒是治疗中结核病患者发生 ATDILI 的一个危险因素。在接受 ATTB 治疗时，患者需要减少饮酒。需要更多的研究来评估饮酒与 ATDILI 之间的联系。
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