核心中的B细胞：根尖周病变中的免疫机制与治疗潜力

B Cells at the Core: Immune Mechanisms and Therapeutic Potentials in Periapical Lesions.

作者信息

Peng Yangqing, Liu Liu, Li Xiangfen, Song Dongzhe, Huang Dingming

机构信息

State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China; Department of Conservative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

出版信息

J Endod. 2025 Jan;51(1):4-14. doi: 10.1016/j.joen.2024.10.003. Epub 2024 Oct 10.

DOI:10.1016/j.joen.2024.10.003

PMID:39393516

Abstract

INTRODUCTION

Periapical lesions (PLs) are common inflammatory diseases primarily caused by microbial infections within root canals. These infections trigger complex immune responses in periapical tissues, with B lymphocytes playing dual roles: defending against pathogens while also contributing to tissue damage. This highlights the crucial role of B cells in the immunological processes of PLs.

METHODS

A comprehensive review of the literature on B cells in PLs was conducted using PubMed, Web of Science, Scopus, and ScienceDirect databases.

RESULTS

The review included 120 studies that examined the distribution and subtypes of B cells, their dual functions in PLs, and the potential applications of B-cell-related therapies in treating apical periodontitis.

CONCLUSIONS

This review enhances our understanding of the complex immune mechanisms in PLs and aids in the development of new therapeutic approaches from a B-cell perspective.

摘要