UMR1227, LBAI, Univ Brest, Inserm, Brest, France.
UMR1227, LBAI, Univ Brest, Inserm, Brest, France; Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Clin Immunol. 2024 Nov;268:110378. doi: 10.1016/j.clim.2024.110378. Epub 2024 Oct 10.
The conventional classification of mature B cells overlooks the diversity within IgD CD27 naïve B cells. Here, to identify distinct mature naïve B cells, we categorized CD45RB B cells (NA RB-) and CD45RB B cells (NA RB+) and explore their function and localization in circulation and tissues under physiological and pathological conditions. NA RB+ B cells, found in secondary lymphoid organs, differentiate into plasmablasts and secrete IgM. In Sjögren's disease, their numbers decrease, and they show over-activation and abnormal migration, suggesting an adaptive disease response. NA RB+ B cells also appear in inflamed salivary glands, indicating involvement in local immune responses. These findings highlight the distinct roles of NA RB+ B cells in health and Sjögren's disease.
传统的成熟 B 细胞分类方法忽略了 IgD CD27 初始 B 细胞的多样性。在这里，为了鉴定不同的成熟初始 B 细胞，我们对 CD45RB B 细胞（NA RB-）和 CD45RB B 细胞（NA RB+）进行了分类，并在生理和病理条件下探索了它们在循环和组织中的功能和定位。在次级淋巴器官中发现的 NA RB+ B 细胞分化为浆母细胞并分泌 IgM。在干燥综合征中，其数量减少，并且表现出过度激活和异常迁移，表明存在适应性疾病反应。NA RB+ B 细胞也出现在发炎的唾液腺中，表明其参与局部免疫反应。这些发现强调了 NA RB+ B 细胞在健康和干燥综合征中的不同作用。
