Nursing Department, The Third Xiangya Hospital, Central South University, 138 Tong Zi Po Road, Changsha, Hunan, 410013, China.
Department of Thyroid Breast Surgery, The Third Xiangya hospital, Central South University, 138 Tong Zi Po Road, Changsha, Hunan, 410013, China.
BMC Cancer. 2024 Oct 11;24(1):1264. doi: 10.1186/s12885-024-13025-8.
Understanding the factors that contribute to variability in breast cancer-related lymphedema (BCRL) is an important first step in developing targeted interventions to improve quality of life in breast cancer patients. Although previous research studies have has identified many risk factors for BCRL, dietary habits and catheterization type have rarely been studied until the present.
This study aims to explore the effects of nursing factors such as dietary habits and catheterization type on breast cancer-related lymphedema (BCRL).
This retrospective cohort study included 1,476 breast cancer patients who underwent surgery between January 1, 2012, and September 1, 2020. Lymphedema was assessed with a validated self-report questionnaire. All research data were obtained from medical records and a follow-up database. Multivariate Cox regression was conducted to explore the effects of dietary habits and catheterization type on BCRL.
The results showed an increased risk for BCRL among breast cancer patients who followed a high-fat diet prehospitalization (HR = 2.47; 95% CI = 1.55-3.94; P < 0.001), indwelling totally implantable venous access ports (TIVAPs) compared with indwelling needles (HR = 0.56; 95% CI = 0.35-0.90;P = 0.017) or indwelling peripherally inserted central catheters (PICCs) (HR = 0.69; 95% CI = 0.45-1.05; P = 0.086).
High-fat diet pre-hospitalization was an independent risk factor for lymphedema. The TIVAPs did not exert a protective effect on lymphedema compared with the PICC and indwelling needle. This study finding offers new insights to develop targeted interventions to decrease the incidence of lymphedema.
了解导致乳腺癌相关淋巴水肿（BCRL）变异性的因素是开发针对乳腺癌患者生活质量干预措施的重要第一步。尽管以前的研究已经确定了许多 BCRL 的风险因素，但直到现在，饮食习惯和导管类型才很少被研究。
本研究旨在探讨饮食习惯和导管类型等护理因素对乳腺癌相关淋巴水肿（BCRL）的影响。
这是一项回顾性队列研究，纳入了 2012 年 1 月 1 日至 2020 年 9 月 1 日期间接受手术的 1476 例乳腺癌患者。淋巴水肿通过经过验证的自我报告问卷进行评估。所有研究数据均从病历和随访数据库中获得。采用多变量 Cox 回归分析探讨饮食习惯和导管类型对 BCRL 的影响。
研究结果显示，与住院前低脂饮食的乳腺癌患者相比，住院前高脂肪饮食的患者发生 BCRL 的风险增加（HR=2.47；95%CI=1.55-3.94；P<0.001），与留置针（HR=0.56；95%CI=0.35-0.90；P=0.017）或留置外周中心静脉导管（PICC）（HR=0.69；95%CI=0.45-1.05；P=0.086）相比，留置完全植入式静脉输液港（TIVAP）的患者发生 BCRL 的风险更高。
住院前高脂肪饮食是淋巴水肿的独立危险因素。与 PICC 和留置针相比，TIVAP 对淋巴水肿没有保护作用。本研究结果为开发针对减少淋巴水肿发生率的干预措施提供了新的见解。
