Hirata Tetsuo, Shiga Yuhei, Tashiro Kohei, Higashi Sara, Tachibana Tetsuro, Kawahira Yuto, Suematsu Yasunori, Kuwano Takashi, Sugihara Makoto, Ogawa Masahiro, Miura Shin-Ichiro
Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan.
Department of Laboratory Medicine, Fukuoka University School of Medicine, Fukuoka, Japan.
Hypertens Res. 2025 Feb;48(2):640-649. doi: 10.1038/s41440-024-01917-y. Epub 2024 Oct 12.
Liver fibrosis scores, such as the fibrosis-4 index (FIB-4I), a representative index of liver fibrosis, have recently been linked to heart failure, coronary artery disease (CAD), and atrial fibrillation (AF). We investigated the association between FIB-4I and AF in patients who underwent coronary computed tomography angiography (CCTA). This study included 1525 patients clinically suspected of having CAD or about to undergo treatment for AF, such as catheter ablation. FIB-4I and the presence or absence of AF were the primary endpoints. FIB-4I was higher in the AF group than in the sinus rhythm group (1.93 ± 0.94 versus [vs.] 1.75 ± 1.03, p = 0.001). No significant difference was observed in the FIB-4I between the paroxysmal AF and persistent AF groups (1.93 ± 0.99 vs. 1.94 ± 0.78, p = 0.922). Furthermore, FIB-4I was higher in the hypertension (HTN) group than in the non-HTN group (1.84 ± 1.04 vs. 1.62 ± 0.91, p < 0.001). Low FIB-4I (≤1.29) was proven to be a contributing factor for the absence of AF in all patients (odds ratio [OR]: 0.55, 95% confidence interval [CI]: 0.39-0.78, p < 0.001) as well as the HTN and non-HTN (OR: 0.53, 95% CI: 0.37-0.78, p < 0.001 and OR: 0.39, 95% CI: 0.23-0.68, p < 0.001, respectively) groups. Thus, FIB-4I may serve as a diagnostic indicator of the absence of AF in patients undergoing CCTA. The liver fibrosis-4 index as a diagnostic indicator of the absence of atrial fibrillation in patients undergoing coronary computed tomography angiography.
肝纤维化评分，如纤维化-4指数（FIB-4I），作为肝纤维化的代表性指标，最近已与心力衰竭、冠状动脉疾病（CAD）和心房颤动（AF）相关联。我们研究了接受冠状动脉计算机断层扫描血管造影（CCTA）的患者中FIB-4I与AF之间的关联。本研究纳入了1525例临床上怀疑患有CAD或即将接受AF治疗（如导管消融）的患者。FIB-4I和AF的有无是主要终点。AF组的FIB-4I高于窦性心律组（1.93±0.94对1.75±1.03，p = 0.001）。阵发性AF组和持续性AF组之间的FIB-4I无显著差异（1.93±0.99对1.94±0.78，p = 0.922）。此外，高血压（HTN）组的FIB-4I高于非HTN组（1.84±1.04对1.62±0.91，p < 0.001）。低FIB-4I（≤1.29）被证明是所有患者中无AF的一个促成因素（优势比[OR]：0.55，95%置信区间[CI]：0.39 - 0.78，p < 0.001），在HTN组和非HTN组中也是如此（OR分别为：0.53，95% CI：0.37 - 0.78，p < 0.001和OR：0.39，95% CI：0.23 - 0.68，p < 0.001）。因此，FIB-4I可作为接受CCTA的患者中无AF的诊断指标。肝纤维化-4指数作为接受冠状动脉计算机断层扫描血管造影的患者中无心房颤动的诊断指标。
