CICS-UBI-Health Sciences Research Centre, Universidade da Beira Interior, Avenida Infante D. Henrique, 6200-506 Covilhã, Portugal.
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Front Neuroendocrinol. 2024 Oct;75:101158. doi: 10.1016/j.yfrne.2024.101158. Epub 2024 Oct 10.
The blood-brain barrier and the blood-cerebrospinal fluid barrier separate the blood from brain tissue and cerebrospinal fluid. These brain barriers are important to maintain homeostasis and complex functions by protecting the brain from xenobiotics and harmful endogenous compounds. The disruption of brain barriers is a characteristic of neurologic diseases. Melatonin is a lipophilic hormone that is mainly produced by the pineal gland. The blood-brain barrier and the blood-cerebrospinal fluid barriers are melatonin-binding sites. Among the several melatonin actions, the most characteristic one is the regulation of sleep-wake cycles, melatonin has anti-inflammatory and antioxidant properties. Since brain barriers disruption can arise from inflammation and oxidative stress, knowing the influence of melatonin on the integrity of brain barriers is extremely important. Therefore, the objective of this review is to gather and discuss the available literature about the regulation of brain barriers by melatonin.
血脑屏障和血脑脊液屏障将血液与脑组织和脑脊液分开。这些脑屏障通过保护大脑免受外源性物质和有害内源性化合物的侵害，对于维持脑内环境稳定和复杂功能非常重要。脑屏障的破坏是神经疾病的一个特征。褪黑素是一种亲脂性激素，主要由松果体产生。血脑屏障和血脑脊液屏障是褪黑素结合位点。在褪黑素的几种作用中，最具特征的是调节睡眠-觉醒周期，褪黑素具有抗炎和抗氧化特性。由于炎症和氧化应激可能导致脑屏障破坏，因此了解褪黑素对脑屏障完整性的影响非常重要。因此，本综述的目的是收集和讨论关于褪黑素调节脑屏障的现有文献。
