Ciammaichella Luca, Cola Veronica, Foglia Armando, Zanardi Stefano, Chalfon Carmit, Tassani Chiara, Avallone Giancarlo, Monari Erika, Pisoni Luciano, Magno Sara Del, Dondi Francesco
Veterinary University Hospital - Department of Veterinary Medical Sciences - Alma Mater Studiorum University of Bologna - Via Tolara di Sopra, 50, Ozzano dell'Emilia (BO), 40064 Italy.
Veterinary University Hospital - Department of Veterinary Medical Sciences - Alma Mater Studiorum University of Bologna - Via Tolara di Sopra, 50, Ozzano dell'Emilia (BO), 40064 Italy.
Top Companion Anim Med. 2024 Nov-Dec;63:100924. doi: 10.1016/j.tcam.2024.100924. Epub 2024 Oct 11.
A 2-year-old female Bengal cat was referred for acute right forelimb lameness one month after ovariectomy. Physical examination revealed multifocal pain on bone palpation and fever. Radiographs showed mixed lytic-proliferative polyostotic diaphyseal osteopathy of multiple bone segments. Histopathologic evaluation of bone biopsies showed severe chronic pyogranulomatous osteomyelitis and multidrug-resistant Serratia marcescens was cultured. Antibiotic therapy with piperacillin-tazobactam was administered for 60 days, based on susceptibility testing. Lameness and bone pain resolved within 15 days, and radiographs after 30 days showed decreased bone lysis. At a 6-month recheck, the cat recovered completely, and only bone remodelling was evident on radiographs. Multifocal bacterial haematogenous osteomyelitis (HO) caused by Serratia marcescens was diagnosed in an adult immunocompetent cat. HO is infrequently reported in dogs and cats with young and immunocompromised patients being most at risk. Prior ovariectomy and anaesthesia may have predisposed the cat to the development of a hospital-associated infection (HAI), as other aetiologies or predisposing causes for osteomyelitis were reasonably excluded. Serratia marcescens is a gram-negative bacterium recently reported as responsible for human and veterinary HAIs, although it has never been stated for HO in small animals. Early recognition and antibiotic therapy led to good outcome in this case.
一只2岁的雌性孟加拉猫在卵巢切除术后1个月因急性右前肢跛行前来就诊。体格检查发现骨骼触诊时有多处疼痛和发热。X线片显示多个骨段有溶骨性-增殖性混合性多骨骨干骨病。骨活检的组织病理学评估显示为严重的慢性脓性肉芽肿性骨髓炎，并培养出耐多药的粘质沙雷氏菌。根据药敏试验，给予哌拉西林-他唑巴坦抗生素治疗60天。跛行和骨痛在15天内缓解，30天后的X线片显示骨溶解减少。在6个月的复查中，猫完全康复，X线片上仅可见骨重塑。诊断为成年免疫功能正常的猫发生了由粘质沙雷氏菌引起的多灶性细菌性血源性骨髓炎（HO）。HO在犬猫中很少报道，年轻和免疫功能低下的患者风险最高。由于合理排除了骨髓炎的其他病因或易感因素，先前的卵巢切除术和麻醉可能使这只猫易患医院获得性感染（HAI）。粘质沙雷氏菌是一种革兰氏阴性菌，最近报道其可导致人和兽医的HAI，尽管在小动物中从未提及它与HO有关。早期识别和抗生素治疗使该病例取得了良好的结果。
