怀地黄新鲜根中的阿朴类胡萝卜素及其抗肺纤维化活性。
Apocarotenoids from the fresh roots of Rehmannia glutinosa and their anti-pulmonary fibrosis activity.
机构信息
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China.
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China; Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-Construction by Henan province & Education Ministry of P. R. China, Zhengzhou 450046, China.
出版信息
Fitoterapia. 2024 Dec;179:106247. doi: 10.1016/j.fitote.2024.106247. Epub 2024 Oct 10.
Six undescribed compounds (1-6) and twenty-three known analogues (7-29) were isolated from the fresh roots of Rehmannia glutinosa. The structures of the compounds (1-29) were established through the application of spectroscopic analysis. Compounds 3, 4, 6, 8, 13, 18, 21, 22, 25, and 28 exhibited excellent anti-pulmonary fibrosis activity. The potential mechanistic pathway of 3 was also investigated, whose results indicate that compound 3 ameliorate TGF-β1 induced BEAS-2B cell injury via PI3K/AKT/NF-κB signaling pathway.
从新鲜地黄根部分离得到六个未描述的化合物（1-6）和二十三个已知类似物（7-29）。通过光谱分析，确定了化合物（1-29）的结构。化合物 3、4、6、8、13、18、21、22、25 和 28 表现出优异的抗肺纤维化活性。还研究了 3 的潜在机制途径，结果表明，化合物 3 通过 PI3K/AKT/NF-κB 信号通路改善 TGF-β1 诱导的 BEAS-2B 细胞损伤。
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