School of Materials Science and Engineering, Xiangtan University, Xiangtan 411105, China.
School of Materials Science and Engineering, Xiangtan University, Xiangtan 411105, China.
Acta Biomater. 2024 Nov;189:633-650. doi: 10.1016/j.actbio.2024.10.012. Epub 2024 Oct 11.
Iron-selenium (Fe-Se) alloys have potential as attractive biodegradable bone-implant materials, given the antitumor properties of Se in cancer prevention and therapy. However, the fabrication of Fe-Se alloys is challenging due to the volatility of elemental Se and the significantly different melting points of Se and Fe. In this study, we successfully fabricated Fe-xSe (x = 0.2, 0.4, 0.6, 0.8, and 1 wt.%) alloys using suction casting, with FeSe compounds as the Se source. The microstructures, tensile properties, corrosion behavior, biocompatibility, antibacterial ability, and antitumor properties of the Fe-Se alloys were evaluated. The microstructures of the Fe-Se alloys were composed of α-Fe and FeSe phases. Among the Fe-Se alloys, Fe-0.6Se showed the best combination of tensile properties, with a yield strength of 1096.5 ± 7.2 MPa, an ultimate tensile strength of 1271.6 ± 6.3 MPa, and a fracture strain of 15.6 ± 3.3 %, and a degradation rate of 56.9 ± 0.4 μm/year. Moreover, the Fe-0.6Se alloy showed superb antibacterial ability against S. aureus, antitumor activity against 143B osteosarcoma cells, and osteogenicity and biocompatibility toward pre-osteoblast MC3T3-E1 cells. In summary, adding 0.2-1.0 wt.% Se to Fe does not affect the growth of healthy cells but effectively inhibits the growth and reproduction of tumor cells, and the Fe-0.6Se alloy is promising for orthopedic applications owing to its unique combination of mechanical and biofunctional properties. STATEMENT OF SIGNIFICANCE: This work reports on Fe-xSe (x = 0.2, 0.4, 0.6, 0.8, and 1 wt.%) alloys fabricated using suction casting. The microstructures of the Fe-Se alloys were composed of α-Fe and FeSe phases. Among the Fe-Se alloys, the Fe-0.6Se showed the best combination of tensile properties, with a yield strength of 1058.6 ± 3.9 MPa, an ultimate tensile strength of 1134.1 ± 2.9 MPa, and a fracture strain of 16.8 ± 1.5 %, and a degradation rate of 56.9 ± 0.4 μm/year. Moreover, the Fe-0.6Se alloy showed superb antibacterial ability against S. aureus, antitumor activity against 143B osteosarcoma cells, and significant osteogenic ability and biocompatibility toward pre-osteoblast MC3T3-E1 cells. In summary, the Fe-0.6Se alloy is promising for orthopedic applications owing to its unique combination of mechanical and biofunctional properties.
铁-硒（Fe-Se）合金作为一种有吸引力的可生物降解的骨植入材料具有潜力，因为硒在癌症预防和治疗中的抗肿瘤特性。然而，由于元素硒的挥发性以及硒和铁的熔点差异很大，因此制造 Fe-Se 合金具有挑战性。在这项研究中，我们成功地使用吸铸法制造了 Fe-xSe（x=0.2、0.4、0.6、0.8 和 1wt.%）合金，其中 FeSe 化合物作为硒源。评估了 Fe-Se 合金的微观结构、拉伸性能、腐蚀行为、生物相容性、抗菌能力和抗肿瘤特性。Fe-Se 合金的微观结构由α-Fe 和 FeSe 相组成。在 Fe-Se 合金中，Fe-0.6Se 表现出最佳的拉伸性能组合，屈服强度为 1096.5±7.2MPa，拉伸强度为 1271.6±6.3MPa，断裂应变为 15.6±3.3%，降解速率为 56.9±0.4μm/年。此外，Fe-0.6Se 合金对金黄色葡萄球菌具有出色的抗菌能力，对 143B 骨肉瘤细胞具有抗肿瘤活性，对前成骨细胞 MC3T3-E1 具有成骨能力和生物相容性。总之，向 Fe 中添加 0.2-1.0wt.% 的 Se 不会影响健康细胞的生长，但能有效抑制肿瘤细胞的生长和繁殖，Fe-0.6Se 合金因其独特的机械和生物功能特性的结合而有望用于骨科应用。
