Lisieska-Żołnierczyk Sylwia, Gajęcka Magdalena, Zielonka Łukasz, Dąbrowski Michał, Gajęcki Maciej T
Independent Public Health Care Center of the Ministry of the Interior and Administration and the Warmia and Mazury Oncology Center in Olsztyn, Wojska Polskiego 37, 10-228, Olsztyn, Poland.
Department of Veterinary Prevention and Feed Hygiene, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 13, 10-718, Olsztyn, Poland.
Toxicon. 2024 Nov 28;251:108125. doi: 10.1016/j.toxicon.2024.108125. Epub 2024 Oct 10.
Mycotoxins are secondary metabolites produced by various species of mold fungi commonly found in plant materials. Zearalenone (ZEN) adversely affects the endocrine system. This study aimed to determine whether thyroid-stimulating hormone (TSH), procalcitonin (PCT), free triiodothyronine (fT3), and free thyroxine (fT4) levels are altered during natural zearalenone mycotoxicosis in patients diagnosed with sigmoid colon cancer (SCC) or colorectal cancer (CRC). A study was conducted on women and men diagnosed with SCC or CRC accompanied by the presence or absence (Patients Without ZEN - PWZ group) of ZEN in the blood. The PWZ group consisted of 17 patients with symptoms of SCC and CRC in whom ZEN and its metabolites were not detected in peripheral blood. The experimental (empirical) groups included a total of 16 SCC and CRC patients who tested positive for ZEN, but not its metabolites. TSH values in both sexes were within the upper limit of the reference range (0.27-4.2 μIU/mL) adopted by the hospital laboratory and corresponded to the upper second tertile and the lower third tertile. PCT values demonstrated that SCC and CRC were accompanied by a systemic or local bacterial infection. All mean values of fT3 were in the middle of the reference range, and the mean values of fT4 were within the upper reference limit. The fT3/fT4 prognostic marker was somewhat above the cut-off point of 0.22. These results indicate that in postmenopausal women and andropausal men who were diagnosed with SCC and CRC and were exposed to food-borne ZEN, higher values of the prognostic marker (fT3/fT4) were associated with an unfavorable prognosis. The study also revealed that the more distal the neoplastic lesions in the colon, the higher the percentage of both thyroid hormones, regardless of the patient's sex. The presence of ZEN in the diet alters thyroid activity in patients diagnosed with SCC and CRC.
霉菌毒素是常见于植物材料中的多种霉菌真菌产生的次生代谢产物。玉米赤霉烯酮（ZEN）会对内分泌系统产生不利影响。本研究旨在确定在被诊断为乙状结肠癌（SCC）或结直肠癌（CRC）的患者发生自然玉米赤霉烯酮霉菌毒素中毒期间，促甲状腺激素（TSH）、降钙素原（PCT）、游离三碘甲状腺原氨酸（fT3）和游离甲状腺素（fT4）水平是否发生改变。对被诊断为SCC或CRC且血液中存在或不存在（无ZEN患者 - PWZ组）ZEN的男性和女性进行了一项研究。PWZ组由17例有SCC和CRC症状且外周血中未检测到ZEN及其代谢产物的患者组成。实验组（经验组）共有16例ZEN检测呈阳性但其代谢产物检测呈阴性的SCC和CRC患者。两性的TSH值均在医院实验室采用的参考范围上限（0.27 - 4.2 μIU/mL）内，分别对应于第二三分位数上限和第三三分位数下限。PCT值表明SCC和CRC伴有全身性或局部细菌感染。所有fT3的平均值处于参考范围中间，fT4的平均值在参考范围上限内。fT3/fT4预后标志物略高于0.22的临界值。这些结果表明，在被诊断为SCC和CRC且接触食源性ZEN的绝经后女性和男性中，预后标志物（fT3/fT4）值较高与不良预后相关。该研究还表明，无论患者性别如何，结肠肿瘤性病变越靠远端，两种甲状腺激素的百分比越高。饮食中ZEN的存在会改变被诊断为SCC和CRC患者的甲状腺活性。
