Department of Dermatology, Peking Union Medical College Hospital, State Key Laboratory of Complex Severe and Rare Diseases, Chinese Academy of Medical Science and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing, PR China.
Department of Dermatology, Peking Union Medical College Hospital, State Key Laboratory of Complex Severe and Rare Diseases, Chinese Academy of Medical Science and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing, PR China.
Int J Infect Dis. 2024 Dec;149:107259. doi: 10.1016/j.ijid.2024.107259. Epub 2024 Oct 10.
This systematic review aims to (1) summarize the demographic and clinical characteristics of patients with nontuberculous mycobacterial (NTM) infections following cosmetic procedures; (2) summarize the frequency of pathogenic NTM species; and (3) review and analyze the antibiotics choice as well as treatment outcomes.
We conducted a systematic search of three electronic databases (Scopus, Embase, and PubMed) from inception to March 31, 2024. We presented demographic and clinical features and the main antibiotic strategy, along with etiological information.
A total of 200 patients were included in the analysis, with a median onset age of 38.0 years. The median latency period before the illness was 28 days. Nodules were the most frequently reported type of lesion, occurring in 31.0% (n = 62/200) of cases. Mycobacterium abscessus was the most commonly found NTM (45%). Clarithromycin was the most commonly applied (64.0%, n = 128/200), followed by amikacin (31.0%, n = 62/200). The median treatment duration was 6 months (0.25, 24). The overall treatment effectiveness rate was 97.4% (n = 148/152).
NTM infections caused by cosmetic procedures are rapidly increasing worldwide and present diagnostic and treatment challenges. Dermatologists and aesthetic practitioners should be aware of this relatively uncommon disease. Further research is needed to standardize management algorithms.
本系统综述旨在：(1)总结美容手术后非结核分枝杆菌（NTM）感染患者的人口统计学和临床特征；(2)总结致病 NTM 菌种的频率；(3)回顾和分析抗生素选择以及治疗结果。
我们从 2024 年 3 月 31 日起，对三个电子数据库（Scopus、Embase 和 PubMed）进行了系统检索。我们呈现了人口统计学和临床特征以及主要的抗生素策略，以及病因信息。
共有 200 例患者纳入分析，中位发病年龄为 38.0 岁。发病前潜伏期中位数为 28 天。结节是最常报告的病变类型，发生在 31.0%（n=62/200）的病例中。脓肿分枝杆菌是最常见的 NTM（45%）。克拉霉素是最常用的抗生素（64.0%，n=128/200），其次是阿米卡星（31.0%，n=62/200）。中位治疗持续时间为 6 个月（0.25-24）。总体治疗有效率为 97.4%（n=148/152）。
全球范围内由美容手术引起的 NTM 感染正在迅速增加，这对诊断和治疗提出了挑战。皮肤科医生和美容医生应该意识到这种相对少见的疾病。需要进一步研究来规范管理算法。
