Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China.
The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei 443000, China; Department of Neurosurgery, Yichang Central People's Hospital, Yichang, Hubei, China.
Brain Res Bull. 2024 Nov;218:111100. doi: 10.1016/j.brainresbull.2024.111100. Epub 2024 Oct 11.
S100A8 (MRP8) and S100A9 (MRP14) are critical mediators of the inflammatory response; they are usually present as heterodimers because of the instability of homodimers. Studies have demonstrated that S100A8/A9 expression is significantly upregulated in several central nervous system (CNS) diseases. S100A8/A9 is actively released by neutrophils and monocytes; it plays a key role in regulating the inflammatory response by stimulating leukocyte recruitment and inducing cytokine secretion during inflammation. Additionally, S100A8/A9 can be used as a diagnostic biomarker for several CNS diseases and as a predictor of therapeutic response to inflammation-related diseases. In this work, we reviewed our current understanding of S100A8/A9 overexpression in inflammation and its importance in the development and progression of CNS inflammatory diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), and stroke, and the functional roles and therapeutic applications of S100A8/A9 in these diseases. Finally, we discussed the current barriers and future research directions of S100A8/A9 in CNS diseases.
S100A8（MRP8）和 S100A9（MRP14）是炎症反应的关键介质；由于同源二聚体的不稳定性，它们通常以异源二聚体的形式存在。研究表明，S100A8/A9 的表达在几种中枢神经系统（CNS）疾病中显著上调。S100A8/A9 由中性粒细胞和单核细胞主动释放；它通过在炎症期间刺激白细胞募集和诱导细胞因子分泌，在调节炎症反应中发挥关键作用。此外，S100A8/A9 可用作几种 CNS 疾病的诊断生物标志物，并可作为炎症相关疾病治疗反应的预测因子。在这项工作中，我们回顾了我们目前对 S100A8/A9 在炎症中的过度表达及其在 AD、PD、MS 和中风等 CNS 炎症性疾病的发展和进展中的重要性的理解，以及 S100A8/A9 在这些疾病中的功能作用和治疗应用。最后，我们讨论了 S100A8/A9 在 CNS 疾病中的当前障碍和未来研究方向。
