Department of Molecular and Cellular Biology, National Centre for Biotechnology (CNB-CSIC), Madrid, Spain.
Rare Diseases Networking Biomedical Research Centre (CIBERER-ISCIII), Madrid, Spain.
Reprod Domest Anim. 2024 Oct;59 Suppl 3:e14670. doi: 10.1111/rda.14670.
The revolution in biology triggered by the different genome-editing tools has of course arrived to the research field of animal reproduction. Yeast meganucleases, zinc-finger nucleases, TALEN and, particularly, the several generations of CRISPR tools have landed in animal reproduction thereby providing novel strategies to optimize or modify some of the features and capabilities of the recipient animals. All these genome-editing proposals and activities are associated with ethical considerations regarding how those planned genome alterations might affect important animal welfare issues. The ethical dimension of all these genome editing must be seriously considered. Hence, all ethical aspects bound to any given genome-edited allele in animals should be discussed in order to ensure that we are maximizing benefits and reducing any potential risk or negative considerations of these modifications. In this review, I will summarize some of the experiments reported aiming to investigate or improve animal reproduction and I will address the ethics issues that should also be considered.
不同基因组编辑工具引发的生物学革命当然也已经进入了动物繁殖研究领域。酵母巨核酸酶、锌指核酸酶、TALEN，特别是几类 CRISPR 工具已经应用于动物繁殖，从而为优化或修饰受体动物的某些特征和功能提供了新的策略。所有这些基因组编辑提案和活动都涉及到关于计划中的基因组改变可能如何影响重要的动物福利问题的伦理考虑。所有这些基因组编辑的伦理维度都必须认真考虑。因此，应该讨论与动物中任何给定的基因组编辑等位基因相关的所有伦理方面，以确保我们最大限度地提高这些修饰的益处，并减少任何潜在的风险或负面考虑。在这篇综述中，我将总结一些旨在研究或改善动物繁殖的已报道实验，并将讨论也应该考虑的伦理问题。
