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肥胖相关代谢状况的评估:一种新型客观评分系统能更好地反映代谢疾病的严重程度。

Assessment of Obesity-related Metabolic Conditions: a novel objective scoring system better informs metabolic disease severity.

作者信息

Lyo Victoria, Arriola John, Ahmed Shushmita M, Mostaedi Rouzbeh, Akinjobi Zainab, Shamseddeen Hazem N, Ali Mohamed R

机构信息

Department of Surgery, University of California, Davis, California; Center for Alimentary and Metabolic Sciences, University of California, Davis, California.

Department of Surgery, University of California, Davis, California.

出版信息

Surg Obes Relat Dis. 2025 Mar;21(3):207-215. doi: 10.1016/j.soard.2024.09.004. Epub 2024 Sep 19.

DOI:10.1016/j.soard.2024.09.004
PMID:39396883
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11805658/
Abstract

BACKGROUND

Reporting of obesity-associated metabolic disease severity and longitudinal response to bariatric surgery is not standardized. We updated our co-morbidity scoring tool to the Assessment of Obesity-related Metabolic Conditions (AOMC) to combine pharmacotherapy and biochemical data to score diabetes mellitus (DM), hypertension (HTN), and dyslipidemia (DYS) severity.

OBJECTIVES

The aim of this study is to determine whether the AOMC system more accurately stages metabolic disease severity than a clinically based Assessment of Obesity-Related Comorbidities (AORC) system.

SETTING

University hospital, United States.

METHODS

A retrospective cohort study of prospectively collected demographic, clinical, and biochemical data was performed on adults evaluated for bariatric surgery over 6years. AORC versus AOMC scores and disease severity were compared using McNemar's and Wilcoxon's tests.

RESULTS

Of 1442 patients, AOMC newly diagnosed metabolic disease in more patients than did AORC: DM (73.4% versus 44.5%), HTN (91.7% versus 67.9%), and DYS (63.8% versus 53.4%). Of those on pharmacotherapy, AOMC found fewer patients with adequately controlled disease: DM (39.9% versus 97.7%), HTN (64.7% versus 99.3%), and DYS (51.8% versus 99.0%). For those in whom both scores could be calculated, disease severity was upstaged in most patients: DM (65.9%), HTN (42.9%), and DYS (30.9%). There were also significant shifts toward higher scores for all conditions and severity classifications, with more patients diagnosed with pre-metabolic and severe disease (untreated/uncontrolled).

CONCLUSIONS

Our study demonstrated that the severity of DM, HTN, and DYS is vastly under-represented by clinical history alone and lacks standardized assessments. Our AOMC tool more accurately describes longitudinal metabolic response to bariatric surgery.

摘要

背景

肥胖相关代谢疾病严重程度的报告以及减肥手术的纵向反应尚未标准化。我们将共病评分工具更新为肥胖相关代谢状况评估(AOMC),以结合药物治疗和生化数据来对糖尿病(DM)、高血压(HTN)和血脂异常(DYS)的严重程度进行评分。

目的

本研究旨在确定AOMC系统相比基于临床的肥胖相关共病评估(AORC)系统,在代谢疾病严重程度分期方面是否更准确。

地点

美国大学医院。

方法

对6年来接受减肥手术评估的成年人进行回顾性队列研究,这些患者的人口统计学、临床和生化数据是前瞻性收集的。使用麦克尼马尔检验和威尔科克森检验比较AORC与AOMC评分及疾病严重程度。

结果

在1442例患者中,AOMC新诊断出代谢疾病的患者比AORC更多:DM(73.4%对44.5%)、HTN(91.7%对67.9%)和DYS(63.8%对53.4%)。在接受药物治疗的患者中,AOMC发现疾病得到充分控制的患者较少:DM(39.9%对97.7%)、HTN(64.7%对99.3%)和DYS(51.8%对99.0%)。对于那些可以计算两种评分的患者,大多数患者的疾病严重程度被上调:DM(65.9%)、HTN(42.9%)和DYS(30.9%)。所有病情和严重程度分类的评分也都有显著向更高分数的转变,更多患者被诊断为代谢前期和严重疾病(未治疗/未控制)。

结论

我们的研究表明,仅靠临床病史对DM、HTN和DYS严重程度的反映严重不足,且缺乏标准化评估。我们的AOMC工具能更准确地描述减肥手术的纵向代谢反应。

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