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凝血因子 XIII 在患者血液管理中的作用。

The role of factor XIII in patient blood management.

作者信息

Žunić Miodrag, Vreča Nino, Bevc Sebastjan

机构信息

Department of Anaesthesiology, Intensive care, and Pain management, University Medical Centre Maribor.

Faculty of Medicine, Univesity of Maribor, Maribor, Slovenia.

出版信息

Blood Coagul Fibrinolysis. 2024 Oct 1;35(7):325-333. doi: 10.1097/MBC.0000000000001326. Epub 2024 Sep 30.

DOI:10.1097/MBC.0000000000001326
PMID:39397731
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11462988/
Abstract

Factor XIII (FXIII), a plasma transglutaminase, is a coagulation factor that plays a crucial role in blood clotting and patient blood management. The studies have demonstrated that FXIII targets a wide range of additional substrates that have an important role in hemostasis, especially in posttraumatic patients, patients undergoing surgery or obstetrics, being involved in wound healing and tissue repair. Morover, FXIII deficiency has also been described and an extensive research has shown that FXIII deficiency is a rare coagulopathy that leads to longer bleeding time, perioperative and postoperative complications and slower wound healing. Present article aims to overview the diverse functions of FXIII and to highlight its role in patient blood management.

摘要

因子 XIII（FXIII）是一种血浆转谷氨酰胺酶，是一种凝血因子，在血液凝固和患者血液管理中起着关键作用。研究表明，FXIII 作用于多种在止血过程中具有重要作用的其他底物，尤其是在创伤后患者、接受手术或产科手术的患者中，参与伤口愈合和组织修复。此外，也有关于 FXIII 缺乏症的描述，大量研究表明，FXIII 缺乏症是一种罕见的凝血病，会导致出血时间延长、围手术期和术后并发症以及伤口愈合缓慢。本文旨在概述 FXIII 的多种功能，并强调其在患者血液管理中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6542/11462988/a5a2102d2a90/blcof-35-325-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6542/11462988/b9ae4ecbce3e/blcof-35-325-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6542/11462988/6724eeb7ddea/blcof-35-325-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6542/11462988/a5a2102d2a90/blcof-35-325-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6542/11462988/b9ae4ecbce3e/blcof-35-325-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6542/11462988/6724eeb7ddea/blcof-35-325-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6542/11462988/a5a2102d2a90/blcof-35-325-g003.jpg

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本文引用的文献

1
Management of severe peri-operative bleeding: Guidelines from the European Society of Anaesthesiology and Intensive Care: Second update 2022.严重围手术期出血的管理：欧洲麻醉学与重症监护学会指南：2022年第二次更新
Eur J Anaesthesiol. 2023 Apr 1;40(4):226-304. doi: 10.1097/EJA.0000000000001803.
2
The impact of acquired coagulation factor XIII deficiency in traumatic bleeding and wound healing.获得性凝血因子 XIII 缺乏对创伤性出血和伤口愈合的影响。
Crit Care. 2022 Mar 24;26(1):69. doi: 10.1186/s13054-022-03940-2.
3
Measuring Factor XIII Inhibitors in Patients with Factor XIII Deficiency: A Case Report and Systematic Review of Current Practices in Japan.
测量因子 XIII 缺乏症患者体内的因子 XIII 抑制剂：一例病例报告及对日本当前实践的系统评价
J Clin Med. 2022 Mar 18;11(6):1699. doi: 10.3390/jcm11061699.
4
Factor XIII-A: An Indispensable "Factor" in Haemostasis and Wound Healing.凝血因子 XIII-A：止血和伤口愈合中不可或缺的“因子”
Int J Mol Sci. 2021 Mar 17;22(6):3055. doi: 10.3390/ijms22063055.
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Clinical Validation of an Automated Fluorogenic Factor XIII Activity Assay Based on Isopeptidase Activity.基于异肽酶活性的全自动荧光因子 XIII 活性测定法的临床验证。
Int J Mol Sci. 2021 Jan 20;22(3):1002. doi: 10.3390/ijms22031002.
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Sustained depletion of FXIII-A by inducing acquired FXIII-B deficiency.通过诱导获得性 FXIII-B 缺乏来持续耗尽 FXIII-A。
Blood. 2020 Dec 17;136(25):2946-2954. doi: 10.1182/blood.2020004976.
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Systematic review of viscoelastic testing (TEG/ROTEM) in obstetrics and recommendations from the women's SSC of the ISTH.产科粘弹性测试（血栓弹力图/旋转血栓弹力图）的系统评价及国际血栓与止血学会女性特别小组委员会的建议
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8
Identification of Potential Novel Interacting Partners for Coagulation Factor XIII B (FXIII-B) Subunit, a Protein Associated with a Rare Bleeding Disorder.鉴定与罕见出血性疾病相关的凝血因子 XIII B（FXIII-B）亚基的潜在新型相互作用伙伴。
Int J Mol Sci. 2019 May 31;20(11):2682. doi: 10.3390/ijms20112682.
9
Pro-coagulant haemostatic factors for the prevention and treatment of bleeding in people without haemophilia.用于预防和治疗非血友病患者出血的促凝血止血因子。
Cochrane Database Syst Rev. 2018 Dec 24;12(12):CD010649. doi: 10.1002/14651858.CD010649.pub2.
10
Acquired factor XIII deficiency: A review.获得性因子 XIII 缺乏症：综述
Transfus Apher Sci. 2018 Dec;57(6):724-730. doi: 10.1016/j.transci.2018.10.013. Epub 2018 Oct 30.