Wang Enhui, Jiang Yanfei, Zhao Chunyue
Beijing Qingyan Boshi Health Management Co., Ltd, No.8, Hangfeng Road, Fengtai District, Beijing, China.
Heliyon. 2024 Sep 28;10(19):e38680. doi: 10.1016/j.heliyon.2024.e38680. eCollection 2024 Oct 15.
Research on the skin is continuously evolving, and it is imperative to select a streamlined and efficient research model. is a free-leaving nematode whose epidermis serves as the primary barrier epithelium, composed of a collagen matrix. Differentiation of the epidermis begins in the middle of embryonic development, including polarization of the cytoskeleton and formation of cell junctions. Cuticle secretion is one of the main developmental and physiological features of the epidermis. Mutations in the collagen genes of individual worms lead to cuticle defects, thereby changing the shape of the animals. The complete genome sequence of indicates that more than 170 different collagen genes may be related to this structure. Collagen is a structural protein that plays an important role in the development of extracellular matrix. Different collagen genes are expressed at different stages of matrix synthesis, which may help form specific interactions between different collagens. The differentiated epidermis also plays a key role in the transmission of hormonal signals, fat storage, and ion homeostasis and is closely related to the development and function of the nervous system. The epidermis also provides passive and active defenses against pathogens that penetrate the skin and can repair wounds. In addition, age-dependent epidermal degeneration is a prominent feature of aging and may affect aging and lifespan. This review we highlight recent findings of the structure and related physiological functions of the cuticle of . In contrast to previous studies, we offer novel insights into the utilization of as valuable models for skin-related investigations. It also encourages the use of as a skin model, and its high-throughput screening properties facilitate the acceleration of fundamental research in skin-related diseases.
对皮肤的研究在不断发展，选择一种精简高效的研究模型势在必行。秀丽隐杆线虫是一种自由生活的线虫，其表皮作为主要的屏障上皮，由胶原基质组成。表皮的分化始于胚胎发育中期，包括细胞骨架的极化和细胞连接的形成。角质层分泌是表皮的主要发育和生理特征之一。单个蠕虫的胶原基因发生突变会导致角质层缺陷，从而改变动物的形状。秀丽隐杆线虫的完整基因组序列表明，超过170种不同的胶原基因可能与这种结构有关。胶原蛋白是一种结构蛋白，在细胞外基质的发育中起重要作用。不同的胶原基因在基质合成的不同阶段表达，这可能有助于形成不同胶原蛋白之间的特定相互作用。分化的表皮在激素信号传递、脂肪储存和离子稳态中也起着关键作用，并且与神经系统的发育和功能密切相关。表皮还为穿透皮肤的病原体提供被动和主动防御，并能修复伤口。此外，年龄依赖性的表皮退化是衰老的一个突出特征，可能会影响衰老和寿命。在这篇综述中，我们重点介绍了秀丽隐杆线虫角质层结构及其相关生理功能的最新研究结果。与以往的研究相比，我们对将秀丽隐杆线虫用作皮肤相关研究的有价值模型提供了新的见解。它还鼓励将秀丽隐杆线虫用作皮肤模型，其高通量筛选特性有助于加速皮肤相关疾病的基础研究。
