A mechanistic review of the pharmacological aspects of Kaempferide as a natural compound.

BACKGROUND

Kaempferide exhibits a range of pharmacological effects, including anti-tumor activity, kidney protection, oxidative stress relief, gastroprotection, and endocrine regulation. The increasing attention surrounding kaempferide, a promising therapeutic agent, has sparked considerable debate, making it a topic of significant interest in recent research.

PURPOSE

This paper aims to provide a comprehensive review of the clinical applications, pharmacological properties, and underlying molecular mechanisms of kaempferide, while also examining its potential for future therapeutic applications in the field of pharmacology.

METHODOLOGY

We used the keywords "kaempferide" and "kaempferide derivatives" to search for relevant articles in Science Direct, PubMed, MEDLINE, and Web of Science databases.

RESULTS

Kaempferide possesses anti-inflammatory, stomach-protective, antioxidant, anti-tumor, and anti-adipogenic activities, and thus has great potential in different systemic therapies. These interactions involve a multitude of pathways that directly or indirectly affect upstream and downstream key molecules.

CONCLUSIONS

Although kaempferide has shown promising potential, its practical applications still require further in-depth investigation. Future research should prioritize elucidating its mechanisms of action, identifying specific therapeutic targets, and optimizing the compound to facilitate its translation into drug development.