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利用真菌IIIMF4011将香叶醇生物转化为geranic酸。

Biotransformation of Geraniol to Geranic Acid Using Fungus IIIMF4011.

作者信息

Shafeeq Haseena, Lone Bashir Ahmad, Ganjoo Ananta, Ayoub Nargis, Kumari Hema, Gairola Sumeet, Gupta Prasoon, Babu Vikash, Ahmed Zabeer

机构信息

CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India.

Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.

出版信息

ACS Omega. 2024 Sep 24;9(40):41314-41320. doi: 10.1021/acsomega.4c03538. eCollection 2024 Oct 8.

DOI:10.1021/acsomega.4c03538
PMID:39398130
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11465272/
Abstract

Geraniol is an important component in essential oils of aromatic plants such as lemongrass, rosa grass, and many others. It can be converted to different high-value products by using microbes/enzymes. The present study aims at the isolation and screening of microbes showing efficient production of geranic acid (a high-value product) from geraniol (a low-value monoterpene). IIIMF4011, isolated from the soil sample of (Lemongrass), showed biotransformation of geraniol to geranic acid. After optimization of reaction parameters, 97-100% conversion of geraniol to geranic acid was obtained after 72 h of incubation at 28 °C. Furthermore, the biotransformation reaction was also carried out in a 3 L fermentor (working volume 1.5 L), and 98.89% conversion was observed. Therefore, an efficient process of geranic acid production using IIIMF4011 was developed.

摘要

香叶醇是香茅、玫瑰草等芳香植物精油中的重要成分。通过微生物/酶，它可以转化为不同的高价值产品。本研究旨在分离和筛选能从香叶醇（一种低价值单萜）高效生产香叶酸（一种高价值产品）的微生物。从（香茅）土壤样本中分离出的IIIMF4011显示出香叶醇向香叶酸的生物转化。在优化反应参数后，在28℃孵育72小时后，香叶醇向香叶酸的转化率达到了97 - 100%。此外，生物转化反应也在3升发酵罐（工作体积1.5升）中进行，观察到转化率为98.89%。因此，开发了一种使用IIIMF4011生产香叶酸的高效工艺。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7305/11465272/d19902ea7047/ao4c03538_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7305/11465272/50bd45cc761c/ao4c03538_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7305/11465272/d5285feb4b91/ao4c03538_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7305/11465272/3377e9f30153/ao4c03538_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7305/11465272/34aefea83364/ao4c03538_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7305/11465272/3532775c1741/ao4c03538_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7305/11465272/d19902ea7047/ao4c03538_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7305/11465272/50bd45cc761c/ao4c03538_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7305/11465272/d5285feb4b91/ao4c03538_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7305/11465272/3377e9f30153/ao4c03538_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7305/11465272/34aefea83364/ao4c03538_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7305/11465272/3532775c1741/ao4c03538_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7305/11465272/d19902ea7047/ao4c03538_0006.jpg

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Biosyntheses of geranic acid and citronellic acid from monoterpene alcohols by Saccharomyces cerevisiae.利用酿酒酵母从单萜醇生物合成香叶酸和香茅酸。
Biosci Biotechnol Biochem. 2021 May 25;85(6):1530-1535. doi: 10.1093/bbb/zbab039.
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Metabolome profiles of the alphaproteobacterial methanotroph Methylocystis sp. Rockwell in response to carbon and nitrogen source.
α变形菌甲烷营养菌 Methylocystis sp. Rockwell 对碳源和氮源响应的代谢组特征。
FEMS Microbiol Lett. 2021 Feb 4;368(2). doi: 10.1093/femsle/fnaa219.
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NAD metabolism and its roles in cellular processes during ageing.NAD 代谢及其在衰老过程中细胞过程中的作用。
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Monoterpenes and Their Derivatives-Recent Development in Biological and Medical Applications.单萜及其衍生物——生物医学应用的最新进展。
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One Hundred Faces of Geraniol.香叶醇的一百张面孔。
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Investigation of monoterpenoid resistance mechanisms in Pseudomonas putida and their consequences for biotransformations.恶臭假单胞菌中单萜类抗性机制的研究及其对生物转化的影响。
Appl Microbiol Biotechnol. 2020 Jun;104(12):5519-5533. doi: 10.1007/s00253-020-10566-3. Epub 2020 Apr 16.
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