Zhao Chenyang, Zheng Tingting, Wang Run, Lin Xiaona, Hu Zhengming, Zhao Zhuofei, Dai Zhifei, Sun Desheng
Department of Ultrasonography, Peking University Shenzhen Hospital, Shenzhen, 518036 Guangdong China.
Department of Biomedical Engineering, College of Future Technology, National Biomedical Imaging Centre, Peking University, Beijing, 100871 China.
Phenomics. 2024 Jun 22;4(3):298-312. doi: 10.1007/s43657-023-00140-y. eCollection 2024 Jun.
Pyroptosis is a newly recognized type of programmed cell death mediated by the gasdermin family and caspase. It is characterized by the formation of inflammasomes and the following inflammatory responses. Recent studies have elucidated the value of pyroptosis induction in cancer treatment. The inflammatory cytokines produced during pyroptosis can trigger immune responses to suppress malignancy. Physical approaches for cancer treatment, including radiotherapy, light-based techniques (photodynamic and photothermal therapy), ultrasound-based techniques (sonodynamic therapy and focused ultrasound), and electricity-based techniques (irreversible electroporation and radiofrequency ablation), are effective in clinical application. Recent studies have reported that pyroptosis is involved in the treatment process of physical approaches. Manipulating pyroptosis using physical approaches can be utilized in combating cancer, according to recent studies. Pyroptosis-triggered immunotherapy can be combined with the original anti-tumor methods to achieve a synergistic therapy and improve the therapeutic effect. Studies have also revealed that enhancing pyroptosis may increase the sensitivity of cancer cells to some physical approaches. Herein, we present a comprehensive review of the literature focusing on the associations between pyroptosis and various physical approaches for cancer and its underlying mechanisms. We also discussed the role of pyroptosis-triggered immunotherapy in the treatment process of physical manipulation.
细胞焦亡是一种新发现的由gasdermin家族和半胱天冬酶介导的程序性细胞死亡。其特征是炎性小体的形成及随后的炎症反应。最近的研究阐明了诱导细胞焦亡在癌症治疗中的价值。细胞焦亡过程中产生的炎性细胞因子可触发免疫反应以抑制恶性肿瘤。癌症治疗的物理方法，包括放射疗法、光基技术（光动力和光热疗法）、超声基技术（声动力疗法和聚焦超声）以及电基技术（不可逆电穿孔和射频消融），在临床应用中是有效的。最近的研究报道细胞焦亡参与了物理方法的治疗过程。根据最近的研究，利用物理方法调控细胞焦亡可用于对抗癌症。细胞焦亡触发的免疫疗法可与原有的抗肿瘤方法联合使用，以实现协同治疗并提高治疗效果。研究还表明，增强细胞焦亡可能会增加癌细胞对某些物理方法的敏感性。在此，我们对文献进行全面综述，重点关注细胞焦亡与各种癌症物理治疗方法之间的关联及其潜在机制。我们还讨论了细胞焦亡触发的免疫疗法在物理治疗过程中的作用。
