Tang Yu, Sun Xin, Tian Jiangke, Lv Yifei, Sun Haiou, Fan Lijun, Guo Tianyuan
Department of Ultrasound, Beijing United Family Hospital Beijing 100015, China.
Department of Ultrasound, Beijing Tiantan Hospital, Capital Medical University Beijing 100070, China.
Am J Transl Res. 2024 Sep 15;16(9):4526-4533. doi: 10.62347/ACRT3772. eCollection 2024.
To investigate the clinical efficacy and influence on thyroid function of ultrasound-guided microwave ablation (UGMWA) in patients with nodular goiter.
A retrospective analysis was conducted on the clinical data of 162 patients with nodular goiter admitted to Beijing United Family Hospital and Beijing Tiantan Hospital, Capital Medical University from January 2021 to December 2022. According to the surgical treatment plan, they were divided into the control group (conventional surgical methods, n=78) and the experimental group (UGMWA, n=84). Thyroid function indicators, surgical time, visual analog scale (VAS) pain scores, complications, and cosmetic effects were compared between the two groups.
All patients recovered and were discharged after treatment. Three months postoperatively, both groups showed lower levels of free triiodothyronine (FT3) and free thyroxine (FT4) compared to pre-surgery levels, while levels of thyroid-stimulating hormone (TSH) were higher. However, compared with the control group, the experimental group had higher FT3 and FT4 levels and lower TSH levels (all P < 0.05). Additionally, patients in the experimental group had shorter surgical time, less intraoperative blood loss, and lower VAS pain scores than those in the control group. Moreover, the postoperative cosmetic effect scores were higher in the experimental group than in the control group (all P < 0.05). Finally, there was no statistically significant difference in the incidence of complications between the two groups (P=0.523).
UGMWA for the treatment of nodular goiters can expedite surgical time, protect thyroid function, reduce postoperative pain scores, and improve cosmetic effects with certain safety.
探讨超声引导下微波消融术（UGMWA）治疗结节性甲状腺肿患者的临床疗效及对甲状腺功能的影响。
回顾性分析2021年1月至2022年12月在北京和睦家医院及首都医科大学附属北京天坛医院收治的162例结节性甲状腺肿患者的临床资料。根据手术治疗方案，将其分为对照组（传统手术方法，n = 78）和试验组（UGMWA，n = 84）。比较两组患者的甲状腺功能指标、手术时间、视觉模拟评分（VAS）疼痛评分、并发症及美容效果。
所有患者治疗后均康复出院。术后3个月，两组患者的游离三碘甲状腺原氨酸（FT3）和游离甲状腺素（FT4）水平均低于术前，而促甲状腺激素（TSH）水平高于术前。然而，与对照组相比，试验组的FT3和FT4水平更高，TSH水平更低（均P < 0.05）。此外，试验组患者的手术时间更短，术中出血量更少，VAS疼痛评分低于对照组。而且，试验组术后美容效果评分高于对照组（均P < 0.05）。最后，两组并发症发生率差异无统计学意义（P = 0.523）。
UGMWA治疗结节性甲状腺肿可加快手术时间，保护甲状腺功能，降低术后疼痛评分，改善美容效果，且具有一定安全性。
