Lv Jian, Zhou Min, Wei Dong, Zhang Caixin, Chen Jingyu, Ye Shugao
Lung Transplantation Department, Wuxi People's Hospital No. 299 Qingyang Road, Liangxi District, Wuxi 214000, Jiangsu, China.
Am J Transl Res. 2024 Sep 15;16(9):4988-4995. doi: 10.62347/ILKV4550. eCollection 2024.
To investigate the high-risk factors for early pulmonary bacterial infection following lung transplantation and their association with long-term mortality.
A retrospective analysis was conducted on 142 lung transplant recipients treated at Wuxi People's Hospital between January 2018 and July 2022. After applying predefined inclusion and exclusion criteria, 111 cases were analyzed. Univariate and multivariate logistic regression analyses were performed to identify independent risk factors for early pulmonary infection post-transplantation. Additionally, univariate and multivariate Cox regression analyses were used to identify independent prognostic factors affecting one-year survival post-transplantation.
Univariate analysis identified age, bacterial infection in donor lungs, and operation duration as risk factors for early pulmonary infection (all P < 0.05). Multivariate analysis was confirmatory for these as independent risk factors (all P < 0.05). Univariate analysis also showed that intraoperative blood loss and oxygenation index impacted one-year survival (P < 0.05). Multivariate analysis was confirmatory for these as independent risk factors (P < 0.05).
Early pulmonary bacterial infection was not found to be an independent factor affecting 1-year survival. However, substantial intraoperative blood loss and a reduced oxygenation index were identified as independent risk factors associated with increased mortality within 1 year post-transplantation.
探讨肺移植术后早期肺部细菌感染的高危因素及其与长期死亡率的关系。
对2018年1月至2022年7月在无锡市人民医院接受治疗的142例肺移植受者进行回顾性分析。应用预先定义的纳入和排除标准后，对111例病例进行分析。进行单因素和多因素逻辑回归分析，以确定移植后早期肺部感染的独立危险因素。此外，使用单因素和多因素Cox回归分析来确定影响移植后一年生存率的独立预后因素。
单因素分析确定年龄、供体肺细菌感染和手术持续时间为早期肺部感染的危险因素（均P<0.05）。多因素分析证实这些为独立危险因素（均P<0.05）。单因素分析还显示术中失血量和氧合指数影响一年生存率（P<0.05）。多因素分析证实这些为独立危险因素（P<0.05）。
早期肺部细菌感染未被发现是影响1年生存率的独立因素。然而，术中大量失血和氧合指数降低被确定为与移植后1年内死亡率增加相关的独立危险因素。
