免疫血液学在诊断阵发性冷性血红蛋白尿中的重要作用：一例临床病例报告

The Vital Role of Immunohematology in Diagnosing Paroxysmal Cold Hemoglobinuria: A Clinical Case Report.

作者信息

Nava Gutiérrez Willy, Villa Cortés Paola, Ramírez Morales Ricardo, Espinoza Garza Juan P, Espinosa Mora Jaime E

机构信息

Hematology and Oncology, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado de Nuevo León (ISSSTELEON), Monterrey, MEX.

Hematology, Universidad de Monterrey, Monterrey, MEX.

出版信息

Cureus. 2024 Sep 13;16(9):e69362. doi: 10.7759/cureus.69362. eCollection 2024 Sep.

DOI:10.7759/cureus.69362

PMID:39398713

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11471295/

Abstract

Paroxysmal cold hemoglobinuria (PCH) is a rare autoimmune hemolytic anemia caused by the binding of IgG immunoglobulins to red blood cells at cold temperatures, leading to hemolysis upon rewarming. The Donath-Landsteiner test can show biphasic hemolysis, leading to diagnosis. There is no consensus, but chemoimmunotherapy with or without plasma exchange is commonly employed. We present the case of a 42-year-old male who experienced symptoms of hemolysis after cold exposure in a semi-arid, warm-climate city.

摘要

阵发性寒冷性血红蛋白尿（PCH）是一种罕见的自身免疫性溶血性贫血，由IgG免疫球蛋白在低温下与红细胞结合引起，复温后导致溶血。Donath-Landsteiner试验可显示双相溶血，从而得以诊断。目前尚无共识，但通常采用化疗免疫疗法，可联合或不联合血浆置换。我们报告了一名42岁男性的病例，他在一个半干旱、气候温暖的城市中暴露于寒冷环境后出现了溶血症状。