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成人脊柱畸形长节段融合术(伴或不伴三柱截骨术)后的早期临床结果和医学并发症

Early clinical outcomes and medical complications following long segment fusion for adult spinal deformity with and without three column osteotomy.

作者信息

Ammanuel Simon G, Page Paul S, Greeneway Garret P, Ansari Darius, Stadler James A

机构信息

Department of Neurological Surgery, University of Wisconsin Hospital and Clinics, Madison, WI, 53792, United States.

出版信息

World Neurosurg X. 2024 Sep 25;24:100415. doi: 10.1016/j.wnsx.2024.100415. eCollection 2024 Oct.

Abstract

BACKGROUND

Surgical treatment of adult spinal deformity (ASD) commonly involves long-segment fusion with or without three column osteotomies (3CO) to provide satisfactory correction of sagittal and coronal balance. While some clinical studies have implicated 3CO as a driver of high surgical complication rates, these prior investigations are limited by small sample size. Herein, we compare early outcomes and adverse events in patients undergoing long segment posterior spinal fusion for ASD with and without 3CO.

METHODS

A multicenter administrative database was queried for patients undergoing elective posterior spinal fusion for ASD. Patients were stratified based upon long segment fusion with and without 3CO. Preoperative patient demographics, procedural characteristics, hospitalization events, and postoperative complication rates were evaluated. Student's -test and Fisher's exact test were utilized where appropriate to compare differences between the two groups for continuous and categorical variables.

RESULTS

340 cases met the inclusion criteria, of which 156 involved 3CO. Patients who required 3CO had a lower rate of preoperative diabetes (22.3 % vs 10.3 %,  = 0.003), higher rates of non-home discharge (26.2 % vs 57.1 %,  < 0.001), longer operation time (245.62 ± 9.45 vs. 434.40 ± 11.65,  < 0.001), and longer length of stay (4.17 ± 0.66 vs. 7.76 ± 0.83,  < 0.001). In terms of complications, 3CO patients had higher rates of deep surgical site infection (0 % vs 3.2 %,  = 0.02), reintubation (0 % vs 4.5 %,  = 0.004), inability to wean off ventilator (0 % vs 2.6 %,  = 0.04), and perioperative blood transfusion (20.1 % vs 76.3 %,  < 0.001).

CONCLUSIONS

In this retrospective analysis, posterior 3CO was frequently undertaken but associated with higher risk for postoperative adverse events following spinal deformity correction.

摘要

背景

成人脊柱畸形(ASD)的外科治疗通常包括长节段融合术,可联合或不联合三柱截骨术(3CO),以实现矢状面和冠状面平衡的满意矫正。虽然一些临床研究认为3CO是导致高手术并发症发生率的原因,但这些先前的研究受样本量小的限制。在此,我们比较了接受长节段后路脊柱融合术治疗ASD且有或无3CO患者的早期疗效和不良事件。

方法

查询一个多中心管理数据库,以获取接受ASD择期后路脊柱融合术的患者。根据有无3CO的长节段融合对患者进行分层。评估术前患者人口统计学特征、手术特征、住院事件和术后并发症发生率。在适当情况下,使用学生t检验和Fisher精确检验来比较两组连续变量和分类变量的差异。

结果

340例符合纳入标准,其中156例涉及3CO。需要3CO的患者术前糖尿病发生率较低(22.3%对10.3%,P = 0.003),非家庭出院率较高(26.2%对57.1%,P < 0.001),手术时间较长(245.62 ± 9.45对434.40 ± 11.65,P < 0.001),住院时间较长(4.17 ± 0.66对7.76 ± 0.83,P < 0.001)。在并发症方面,3CO患者深部手术部位感染发生率较高(0%对3.2%,P = 0.02),再次插管率较高(0%对4.5%,P = 0.004),脱机困难率较高(0%对2.6%,P = 0.04),围手术期输血率较高(20.1%对76.3%,P < 0.001)。

结论

在这项回顾性分析中,后路3CO手术经常进行,但与脊柱畸形矫正术后较高的不良事件风险相关。

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