Murtada Daniel, Daher Mohammad, Aoun Marven, Mouawad Antoine, Kreichati Gaby, Kharrat Khalil, Sebaaly Amer
Saint Joseph University, Faculty of Medicine, Beirut, Lebanon.
Department of Orthopedic Surgery, Brown University, Providence, RI, USA.
World Neurosurg X. 2024 Sep 21;24:100404. doi: 10.1016/j.wnsx.2024.100404. eCollection 2024 Oct.
Venous thromboembolism (VTE) associated with bony fractures have been documented in the literature. However, the literature is not very exhaustive when it comes to VTE associated with traumatic spine fractures. Thus the purpose of this systematic review analyzing the incidence of VTE associated with spinal trauma.
An electronic search strategy was elaborated in Pubmed, Cochrane Library and Google Scholar (page 1-20) since inception till November 2023.
Twelve studies were included with three prospective clinical studies, seven retrospective studies, one observational cohort study, and one propensity-matched analysis. These involved 256,107 subjects with 6039 concomitant VTE (2.4 %). Potential risk factors included age, D-dimer levels, length of hospital stay, associated spinal cord injury, location of the vertebral trauma and other baseline patient-dependent characteristics.
This review found that the rate VTE in spinal trauma patients was 2.4 % (6039/256107). To optimize care, clinical decision making should be tailored to each patient using a combined approach of imaging, laboratory findings, and serial physical examinations.
文献中已记载了与骨折相关的静脉血栓栓塞症（VTE）。然而，在与创伤性脊柱骨折相关的VTE方面，文献并不十分详尽。因此，本系统评价旨在分析与脊柱创伤相关的VTE的发生率。
自数据库建立至2023年11月，在PubMed、Cochrane图书馆和谷歌学术（第1 - 20页）中制定了电子检索策略。
纳入了12项研究，其中包括3项前瞻性临床研究、7项回顾性研究、1项观察性队列研究和1项倾向匹配分析。这些研究涉及256,107名受试者，其中6039人并发VTE（2.4%）。潜在风险因素包括年龄、D - 二聚体水平、住院时间、合并脊髓损伤、椎体创伤部位以及其他依赖患者的基线特征。
本综述发现，脊柱创伤患者的VTE发生率为2.4%（6039/256107）。为优化治疗，临床决策应采用影像学、实验室检查结果和系列体格检查相结合的方法，根据每个患者的情况进行调整。
